Use of Electron Spin Resonance to Study Complex Biological Membranes
This paper attempts to provide an overview of experimental considerations, possibilities, and problems in the use of spin labels to study the membranes of complex biological systems, especially living cells. There are increasing numbers of reports of such studies that approach problems of both fundamental and medical significance, but there is a lack of systematic reviews of experimental aspects of such studies of complex biological systems. It therefore seems timely and desirable to present a summary of the state of this field. There are abundant excellent reports of the basics of this technique and its application to model membranes (e.g., Berliner, 1976; Gaffney and Chen, 1977; Schreier et al., 1978) so I shall not attempt to cover that material.
KeywordsElectron Spin Resonance Spin Label Duchenne Muscular Dystrophy Hyperfine Splitting Complex Biological System
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