Utilizing Mast Cells and Basophils to Study Lipoxygenase Involvement in Membrane Activation

  • Albert M. Magro
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 71)


An integral part of the immune response is the ability of membrane-bound immunoglobulin to initiate cellular events upon interaction with antigen. The ability of the membrane to translate messages of antigen presence is an important aspect of cellular activation and is dependent upon the enzymatic processes which are initiated. In exploring the enzymatic processes of cellular activation, one should select a system where the response of the cell can take place, on interaction of antigen with antibody, without the necessity of other fluid phase extracellular macromolecules. In addition, stimulation should lead to an immediate response for which there are efficient quantitative assays. A system which has these attributes is the in vitro release of histamine from mast cells or basophils. In this system the interaction of cells and inducing agent initiates the exocytosis of histamine within minutes, and this activation can take place in vitro totally independent of extracellular macromolecular species. The rapid time-course allows experiments to be completed within convenient time periods, and the response in terms of the histamine released can be accurately measured with facility.


Mast Cell Arachidonic Acid Histamine Release Arachidonic Acid Release Human Basophil 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Albert M. Magro
    • 1
  1. 1.Kidney Disease Institute, Center for Laboratories and ResearchNew York State Department of HealthAlbanyUSA

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