Advertisement

Stable Biomembrane Surfaces Formed by Phospholipid Polymers

  • Otto Albrecht
  • David S. Johnston
  • Carmen Villaverde
  • Dennis Chapman
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 71)

Abstract

Many studies have now been made of the structure and dynamics of biomembranes and it is generally accepted that a lipid bilayer provides a matrix in or upon which proteins and glycoproteins are locatedl. It is significant that within some cell membranes the lipids are asymmetrically distributed. All the phosphatidylserine and phosphatidylethanolamine of blood plasma erythrocyte2 and platelet cells3 lie in the inner lamella of the bilayer and all the phosphatidylcholine and sphingomyelin in the outer layer2,3. It has been suggested that this asymmetric phospholipid distribution may serve a biological purpose by helping to maintain the delicate balance between haemostasis and thrombosis. Recent results indicate that the outer surface of blood cells is devoid of phospholipids which are active in blood coagulation processes4.

Keywords

Contact Angle Acyl Chain Hydrophilic Surface Arachidic Acid Phospholipid Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P.J. Quinn and D. Chapman, (1980) in: “Critical Reviews in Biochemistry”, G. Fasman, ed., CRC Press, Cleveland, pp. 1–117.Google Scholar
  2. 2.
    M.S. Bretscher (1973), Science 181, 622–629.PubMedCrossRefGoogle Scholar
  3. 3.
    H.J. Chap, R.F.A. Zwaal and L.L.M. van Deenen (1977), Biochim. Biophys. Acta 467, 146–164.Google Scholar
  4. 4.
    R.F.A. Zwaal, P. Comfurius and L.L.M. van Deenen (1977), Nature 268, 358–360.PubMedCrossRefGoogle Scholar
  5. 5.
    D.S. Johnston, S. Sanghera, M. Pons and D. Chapman(1980), Biochim. Biophys. Acta 602, 57–69.Google Scholar
  6. 6.
    G. Lieser, B. Tieke and G. Wegner (1980), Thin Solid Films 68, 77–90.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Otto Albrecht
    • 1
  • David S. Johnston
    • 1
  • Carmen Villaverde
    • 1
  • Dennis Chapman
    • 1
  1. 1.Department of Biochemistry and ChemistryRoyal Free Hospital School of MedicineLondonUK

Personalised recommendations