High Resolution NMR Spectroscopy in Liquids and Solids
High resolution nuclear magnetic resonance (NMR) spectroscopy has been widely used to examine molecular structures, probe intricate conformational details and study dynamic chemical processes in solution. For samples constrained to be examined in the solid state, either for solubility reasons or because sample properties are modified in solution, conventional liquid state NMR techniques have not been very useful. The recent development of rare spin doubleresonance techniques together with magic angle sample spinning has permitted high resolution spectra to be obtained for solid samples. Of course, the advances in solid state NMR techniques are based largely on the remarkable progress in liquid state Fourier transform NMR that preceded it. Today NMR is among the more rapidly expanding branches of chemical science because it is one of relatively few techniques applicable to the study of molecules in both liquid and solid phases. In the area of biological chemistry, comparisons of spectral properties in the two states can provide significant new insights into local electronic structures in important molecules such as amino acids and proteins as well as complement crystallographic data in the interpretation of experimental results.
KeywordsNuclear Magnetic Resonance Magic Angle Magic Angle Spinning Nuclear Magnetic Resonance Signal Nuclear Magnetic Resonance Experiment
Unable to display preview. Download preview PDF.
- D. L. Vander Hart, W. L. Earl and A. N. Garroway, J. Mag. Reson. 44, 361 (1981).Google Scholar