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Microsomal Ethanol Oxidation: Activity in Vitro and in Vivo

  • Mary K. Roach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 56)

Abstract

The oxidation of ethanol to acetaldehyde by components of the microsomal fraction of mammalian liver has been proposed as a route of alcohol metabolism ancillary to the alcohol dehydrogenase pathway (1, 2, 3, 4, 5). First reported by Orme-Johnson and Ziegler in 1965 (6), the in vitro reaction has since been examined in a number of laboratories. These studies have produced conflicting opinions of the enzymic mechanism, however. Initially, the reaction was thought to be mediated by the hepatic microsomal drug detoxification enzymes in a mechanism that did not involve either of the known alcohol oxidizing enzymes, alcohol dehydrogenase or catalase (1, 2, 6). The possibility of a mutual pathway for the metabolism of alcohol and other drugs stimulated great interest in this process. Later evidence indicated, however, that the reaction was hydrogen peroxide dependent, and it was suggested that catalase,as a contaminant of the microsomes, was the enzyme responsible for the conversion of ethanol to acetaldehyde (7, 8, 9, 10).

Keywords

Ethanol Oxidation Ethanol Metabolism Mixed Function Oxidase Alcohol Metabolism Aldehyde Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Mary K. Roach
    • 1
  1. 1.Section of BiochemistryTexas Research Institute of Mental Sciences Texas Medical CenterHoustonUSA

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