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Genetic Determinants of Alcohol Addiction

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Biochemical Pharmacology of Ethanol

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 56))

Abstract

Alcoholism, like schizophrenia, depression, and some other psychiatric conditions, tends to run in families. In studying a familial disorder, it is important to determine whether the illness is influenced by heredity. Some maintain that truly separating “nature” from “nurture” is impossible, but nevertheless, through the years, there have been a number of studies and much speculation concerning a possible role of heredity in alcoholism.

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References

  1. Wolff, P.H., Ethnic differences in alcohol sensitivity. Science 175: 449–450, 1972.

    Article  PubMed  CAS  Google Scholar 

  2. Ewing, J., Rouse, B.A. and Pellizzari, E.D. Alcohol sensitivity and ethnic background. Am. J. Psychiat. 131: 206–210, 1974.

    PubMed  CAS  Google Scholar 

  3. Fenna, D., Mix, L., Schaefer, O. and Gilbert, J.A.L. Ethanol metabolism in various racial groups. Canad. M.A. J. 105: 472–475, 1971.

    CAS  Google Scholar 

  4. Goodwin, D.W. Is alcoholism hereditary? A review and critique. Arch. of Gen. Psychiat. 25: 545–549, 1971.

    Article  CAS  Google Scholar 

  5. Rybakow, T. Alkoholismus und Erblichkeit. Mschr. Psychiat. Neurol. 20 (suppl.): 221, 1906.

    Article  Google Scholar 

  6. Kraepelin, E. Psychiatrie, (ed.) 8. Leipzig, J.A. Barth, Vol. 2, 1910.

    Google Scholar 

  7. Binswanger, L. Alkoholismus, Neue Deutsche Klinik. Vol. 1, Urban & Schwarzenberg, Berlin, 1928.

    Google Scholar 

  8. Luxenburger, H. Demographische und psychiatrische Untersuchungen in der engeren biologischen Familie von Paralytikerehegatten. Z Ges. Neurot. Psychiat. 112: 331, 1928.

    Article  Google Scholar 

  9. Bleuler, M. Psychotische Belastung von korperlich Kranken. Z. Ges. Neurol. Psychiat. 142: 780, 1932.

    Article  Google Scholar 

  10. Sjogren, T. Genetic-statistical and psychiatric investigations of a west Swedish population. Acta Psychiat. Neurol. (suppl) 52, 1948.

    Google Scholar 

  11. Fremming, K.H. Sygdomsrisikoen for Sindslidelser og andre sjaeledige Abnormtilstande i den danske Gennemsnitsbefolkning. Ejnar Munksgaard, Copenhagen, 1947.

    Google Scholar 

  12. Slater, E. The incidence of mental disorder. Ann. Eugenics 6: 172, 1935.

    Article  Google Scholar 

  13. Boss, M. Zur Frage der erbbiologischen Bedeutung des Alkohols. Mschr. Psychiat. Neurol. 72: 264, 1929.

    Article  Google Scholar 

  14. Pohlisch, K. Soziale und personliche Bedingungen des chronischen Alcoholismus, in Sammlung psychiatrischer und neurologischer Einzeldarstellungen. Leipzig, Germany, G. Thieme Verlag, 1933.

    Google Scholar 

  15. Brugger, C. Familienuntersuchungen bei Alkoholdeliranten. Z. Ges. Neurol. Psychiat. 151: 740, 1934.

    Article  Google Scholar 

  16. Amark, C. A study in alcoholism: clinical, social-psychiatric and genetic investigations. Acta Psychiat. Neurol. Scand. (suppl) 70, 1951.

    Google Scholar 

  17. Gregory, I. Family data concerning the hypothesis of hereditary predisposition toward alcoholism. J. Ment. Sci. 106: 1068, 1960.

    PubMed  CAS  Google Scholar 

  18. Winokur, G. and Clayton, P.J. Family history studies: IV. Comparison of male and female alcoholics. Quart. J. Stud. Alcohol 29: 885–891, 1968.

    PubMed  CAS  Google Scholar 

  19. Dahlberg, G. and Stenberg, S. Alkoholismen som Samhalisproblem. Stockholm, Oskar Eklunds, 1934.

    Google Scholar 

  20. Winokur, G., Reich, T. Rimmer, J. et al. Alcoholism: III. Diagnosis and familial psychiatric illness in 259 alcoholic probands. Arch. Gen. Psychiat. 23: 104–111, 1970.

    Google Scholar 

  21. Rimmer, J. and Chambers, D.S. Alcoholism: Methodological considerations in the study of family illness. Amer. J. Orthopsychiat. 39: 760–768, 1969.

    Article  PubMed  CAS  Google Scholar 

  22. Kroon, H.M. Die Erblichkeit der Trunksucht in der Familie X. Genetica 6: 391, 1924.

    Article  Google Scholar 

  23. Guze, S., Wolfgram, E. and McKinney, J. Psychiatric illness in the families of convicted criminals: A study of 519 first degree relatives. Dis. Nerv. Sys. 28: 651–659, 1967.

    CAS  Google Scholar 

  24. Kaij, L., Alcoholism in twins. Studies on the etiology and sequels of abuse of alcohol, Department of Psychiatry, University of Lund, Almqvist Wiksell, Lund, 1960.

    Google Scholar 

  25. Partanen, J., Bruun, K. and Markkanen, T. Inheritance of Drinking Behavior. Rutgers University Center of Alcohol Studies, New Brunswick, New Jersey, 1966.

    Google Scholar 

  26. Roe, A. and Burks, B. Adult adjustment of foster children of alcoholic and psychotic parentage and the influence of the former home. Memoirs of the Section on Alcohol Studies, Yale University No. 3, Quart. J. Stud. Alcohol, New Haven, 1945.

    Google Scholar 

  27. Goodwin, D.W., Schulsinger, F., Hermansen, L., Guze, S.B. and Winokur G. Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch. of Gen. Psychiat. 28: 238–243, 1973.

    Article  CAS  Google Scholar 

  28. Feighner, J.P. et al. Diagnostic criteria for use in psychiatric research. Arch. Gen. Psychiat. 26: 57–63, 1972.

    Article  PubMed  CAS  Google Scholar 

  29. Schuckit, M.A., Goodwin, D.W. and Winokur, G. A study of alcoholism in half siblings. Am. J. Psychiat. 128: 12 2126, 1972.

    Google Scholar 

  30. Nordmo, S.H. Blood groups in schizophrenia, alcoholism and mental deficiency. Am. J. Psychiat. 116: 460, 1959.

    PubMed  CAS  Google Scholar 

  31. Achte, K. Korreloituvatko ABO-veriryhmat ja alkoholismi (Correlation of ABO blood groups with alcoholism). Duodecim. 74: 20, 1958.

    PubMed  CAS  Google Scholar 

  32. Camps, F.E. and Dodd, B.E. Increase in the incidence of nonsecretors of ABH blood group substances among alcoholic patients. Brit. J. Med. 1: 30, 1967.

    Google Scholar 

  33. Peeples, E.E.Taste Sensitivity to Phenylthiocarbamide in Alcoholics,Master’s thesis. Stetson University, Deland, Fla., 1962.

    Google Scholar 

  34. Cruz-Coke, R. and Varela, A. Inheritance of alcoholism. Lancet 2: 1282, 1966.

    Google Scholar 

  35. Fialkow, P.J., Thuline, M.C. and Fenster, R.F. Lack of association between cirrhosis of the liver and the common types of color blindness. New Eng. J. Med. 275: 584, 1966.

    Google Scholar 

  36. Thuline, M.C. Colour blindness and alcoholism. Lancet 1: 274, 1967.

    Google Scholar 

  37. Dittrich, H., Neubauer, 0. Storungen des Farbsehens bei Leberkrankheiten Munchen Med. Wschr. 109: 2690, 1967.

    Google Scholar 

  38. Popham, R.E., DeLint, J.E.E. and Schmidt, W. Inheritance of Drinking Behavior. Alkoholpolitik, No. 3, 1967.

    Google Scholar 

  39. Hebb, D.O. A Textbook of Psychology. W.B. Saunders, Co., Philadelphia, 1958.

    Google Scholar 

  40. Goldstein, A. Biostatistics: An Introductory Text. The MacMillan Company, New York, 1964.

    Google Scholar 

  41. Varela, A., Rivera, L., Mardones, J. et al. Color vision defects in non-alcoholic relatives of alcoholic patients. Brit. J. Addict. 64: 67–73, 1969.

    Google Scholar 

  42. Winokur, G. X-Borne recessive genes in alcoholism, letters to the editor. Lancet 2: 466, 1967.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA

    Donald W. Goodwin

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  1. Donald W. Goodwin
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Editor information

Editors and Affiliations

  1. Laboratory of Alcohol Research, National Institute on Alcohol Abuse and Alcoholism, Washington, D.C., USA

    Edward Majchrowicz

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© 1975 Plenum Press, New York

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Goodwin, D.W. (1975). Genetic Determinants of Alcohol Addiction. In: Majchrowicz, E. (eds) Biochemical Pharmacology of Ethanol. Advances in Experimental Medicine and Biology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7529-6_18

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  • DOI: https://doi.org/10.1007/978-1-4684-7529-6_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7531-9

  • Online ISBN: 978-1-4684-7529-6

  • eBook Packages: Springer Book Archive

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