Interaction of Biogenic Amines with Ethanol
Ethanol ingestion produces physiological responses which suggest increased sympathetic activity. Heart rate and systolic blood pressure usually rise while sweating and flushing often occur. The euphoria and garrulousness also suggest central sympathetic activation. Experiments in volunteers treated with a depletor of norepinephrine, α- methyltyrosine, and then ethanol, show a lessening of these commonly observed effects of the drug.
KeywordsBiogenic Amine Respiratory Depression Ethanol Ingestion Chromaffin Granule Aldehyde Reductase
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- Davis, V.E.: Alcohol and aberrant metabolism of biogenic amine.Google Scholar
- In: Biological Aspects of Alcohol. M.K. Roach, W.W. Mclsaac and P.J. Creavens (eds.), University of Texas Press, Austin, Texas, pp. 293–312, 1971.Google Scholar
- Gursey, D. and Olson R.E.: Depression of serotonin and norepinephrine levels in rabbit brain. Proc. Soc. Exp. BioZ. Med., 104: 280–281, 1960.Google Scholar
- Leete, E.: Biogenesis of morphine. J. Am. Chem. Soc., 81: 39483951, 1959.Google Scholar
- Majchrowicz, E.: Induction of physical dependence on alcohol and associated metabolic and behavioral changes in the rat. Pharmacologist, 15: 159, Abs., 1973a.Google Scholar
- Majchrowicz, E.: Spectrum and continuum of ethanol intoxication and withdrawal in rats. Pharmacologist, 16: 304, Abs., 1974.Google Scholar
- Robinson, R.: The structural relations of natural products. Clarendon Press, Oxford, 82, 1955.Google Scholar
- Smith, A.: Some relationships between catecholamines and morphine-like drugs. In: Adv. Biol. Psychiat., 6: 208–213, 1963.Google Scholar
- Smith, A. and Gitlow, S.: Effect of disulfiram and ethanol on the catabolism of norepinephrine in man. In: Biochemical Factors in Alcoholism. R.P. Maickel (ed.), pp. 53–99, Pergamon Press, New York, 1967.Google Scholar
- Smith, A., Engelsher, C. and Crofford, M.: Respiratory depressive effects of ethanol: mediation by serotonin. In: Alcohol Intoxication and Withdrawal: Experimental Studies, Adv. Exper. Med. Biol., M. Gross (ed.), Plenum Press, New York, In press, 1974.Google Scholar
- Tabakoff, B. and Erwin, B.G.: Purification and characterization of a reduced NADP-linked aldehyde reductase from brain. J. BioZ. Chem., 245: 3263–3268, 1970.Google Scholar