Many drugs given to mothers and their newborns are bound to albumin. After 25 years of experience in the United States, sulfisoxazole still remains as the only drug clearly associated with an epidemic of kernicterus in newborn infants; however, several other drugs that are often used and most of the newer drugs being developed for possible use in the perinatal period have not been adequately tested for their effects on bilirubin binding, distribution, and metabolism. As the routine use of multiple drugs increases in high-risk newborns, it is appropriate to review the methods available for testing bilirubin-drug interactions. In this presentation we shall review several methods potentially useful for studying bilirubin displacement from albumin by drugs, using examples from our own laboratory.
KeywordsAlbumin Ratio Diamino Diphenyl Sulfone Diphenyl Sulfone Bilirubin Binding Free Bilirubin
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