Distribution of Bilirubin between Serum and Cerebrospinal Fluid in Newborn Infants

  • P. Meisel
  • D. Jährig
  • I. Weinke
  • K. Jährig


An increased bilirubin (BR) concentration in the cerebrospinal fluid (CSF) is found in newborns either in hyperbilirubinemia or after extravasation of blood into CSF and/or increasing CSF protein concentration. We have hypothesized that the BR concentration of CSF may reflect the pigment level in the brain. Therefore, the estimation of the relationship between circulating bilirubin and its CSF level should offer the possibility to gain some insight into the pathogenesis of BR encephalopathy1. Moreover, more subtle indication criteria are necessary to decide whether phototherapy or exchange transfusion is advisable for the treatment of jaundiced infants.


Exchange Transfusion Neurodevelopmental Outcome Neonatal Jaundice Congenital Toxoplasmosis Bromocresol Green 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • P. Meisel
    • 1
  • D. Jährig
    • 1
  • I. Weinke
    • 1
  • K. Jährig
    • 1
  1. 1.Department of PediatricsErnst-Moritz-Arndt UniversityGreifswaldG.D.R.

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