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Long Term Outcome of Phototherapy; Selected Aspects of the Nichhd Cooperative Phototherapy Study

  • Audrey K. Brown
  • Mae Hee Kim
  • Delores Bryla

Abstract

In 1974, a six-center* cooperative clinical trial of photo-therapy for the treatment of neonatal hyperbilirubinemia was initiated by the National Institute of Child Health and Human Development (NICHHD), National Institutes of Health (NIH). Infants were randomized into control or phototherapy groups by a code established by the Biometry Branch of the NICHHD. Randomization was applied to each of the birth-weight groups, <2000 g, 2000–2499 g, and 2500 g or greater. Sex and race were also used in cohorting for randomization. Infants entered the study according to the following criteria:
  1. 1)

    All infants with birth weights <2000 g were entered at 24 ± 12 hours of age (922 infants).

     
  2. 2)

    Infants with birth weights 2000–2499 g were entered if the serum bilirubin reached 10 mg/dL within the first 96 hours after birth (141 infants).

     
  3. 3)

    Infants with birth weights <2499 g were entered if the serum bilirubin reached 13 mg/dL in the first 96 hours after birth. Before October 1974, the level of bilirubin for accession in this weight group was 15 mg/dL (276 infants).

     

Keywords

Serum Bilirubin Exchange Transfusion Perinatal Asphyxia Control Infant Neonatal Hyperbilirubinemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Audrey K. Brown
    • 1
  • Mae Hee Kim
    • 1
  • Delores Bryla
    • 1
  1. 1.Department of PediatricsState University of New York Downstate Medical CenterNew YorkUSA

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