Integral Membrane Glycoproteins in Cell-Cell and Cell-Substratum Adhesion

  • Caroline H. Damsky
  • Karen A. Knudsen
  • Clayton A. Buck


The focus of this chapter is on the integral membrane glycoproteins of the animal cell involved in cell-cell and cell-substratum adhesion. The approach to the subject, both intellectually and experimentally, reflects not only the prejudices of the authors but also the ideas and concepts gleaned from the literature and from conversations with colleagues. For the free interchange of ideas, we are grateful; for misinterpretations or oversights, we apologize. We have focused attention on that body of experimental data that has used both biochemical and biological approaches in an attempt to understand the adhesion process. Immunology, with its potential for specificity, has played a particularly crucial role in the discovery of adhesion-related glycoproteins and, with the increased use of monoclonal antibody technology, will play an increasingly important role in exploring this area. It is a tool that must be used with caution, however, as will be noted throughout the chapter.


Neural Retina Focal Contact Chick Embryo Fibroblast Adhesion Ligand Dependent Aggregation 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Caroline H. Damsky
    • 1
  • Karen A. Knudsen
    • 1
  • Clayton A. Buck
    • 1
  1. 1.The Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

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