Characteristics of Spontaneous Formation of Vasopressor Principle (VA) and of Plasma Kinin as Revealed by Temperature Changes

  • Désirée Armstrong
  • H. Croxatto
  • J. Roblero
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


Normal human serum in polyethylene vessels between 37°and 0°C spontaneously produces at least three vasomotor substances. They include a vasopressor substance called VA, a large molecular depressor substance, here called TPD kinin, and the better known plasma kinin.


Normal Human Serum Amino Caproic Acid Hexadimethrine Bromide Bean Trypsin Inhibitor Polyethylene Vessel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Armstrong, D. (1968). The effects of temperature on the response of human plasma kinin-forming system to promoting and inhibiting agents. Br. J. Pharmac. 34, 670P.Google Scholar
  2. 2.
    Armstrong, D. 1969a ). Actions on the human cold-activated plasma kinin-forming system of pre-heating at 56° and 60°C. Pharm. Res. Comm. 1: 30–35.Google Scholar
  3. 3.
    Armstrong, D. (1969b). Hageman Factor and the spontaneous human plasma-kinin generation occurring in homogeneous media. Activation and inactivation. In: Inflammation, Biochemistry and Drug Interaction. Ed. Bertelli, A. and Houck, C. pp 153–169. Excerpta Medica Foundation, Amsterdam.Google Scholar
  4. 4.
    Armstrong, D. (1970). Pain. In: Heffter’s Handbuch der experimentellen Pharmakologie: Bradykinin: Kallidin: Kallikrein. Ed: Erd8s, E. G. pp 434–481 New York: Springer Verlag.Google Scholar
  5. 5.
    Armstrong, D. and Dias Da Silva, W. (1970). Kinin formation in human blood serum induced by cooling and by heat aggregated human gamma globulin preparations. In: Bradykinin and Related Kinins. Eds. Sicuteri, F., Back, N. and Rocha e Silva, M. pp 3137. New York: Plenum Press.Google Scholar
  6. 6.
    Armstrong, D., Jepson, J. B., Keele, C.A., and Stewart, J. W. (1955). Activation by glass of pharmacologically active agents in blood of various species. J. Physiol. 129, 80–81 P.PubMedGoogle Scholar
  7. 7.
    Armstrong, D., Jepson, J. B., Keele, C. A. and Stewart, J. W. (1957). Pain-producing substance in human inflammatory exudates and plasma. J. Physiol. 135, 350–370.PubMedGoogle Scholar
  8. 8.
    Armstrong, D. and Mills, G. L. (1965). The reversible cold-induced activation of the human plasma kininforming system between 37° and 0°C. J. Physiol. 179, 89–90 P.Google Scholar
  9. 9.
    Armstrong, D., Mills, G. L. and Sicuteri, F. (1966). Physiological influence on the liberation of human plasma kinin at low temperatures. In: Symposium on Hypotensive Peptides. Ed: Erdös, E. G., Back, N. and Sicuteri, F. pp. 139–148. New York: Springer Verlag.CrossRefGoogle Scholar
  10. 10.
    Armstrong, D., Mills, G. L. and Stewart, J. W. (1967). Thermally induced effects on the kinin-forming system of native human plasma, 37°–0°C.and 37°–50°C. In: International Symposium on Vasoactive Polypep-tides; Bradykinin and Related Kinins. Ribeirão Prêto, August 1966; Eds: Rocha e Silva, M. and Rothschild, H. A. pp 167–176. Sao Paulo: Soc: Bras. Farmacologia e Terapêutica Experimental.Google Scholar
  11. 11.
    Armstrong, D. and Stewart, J. W. (1962). Antiheparin agents as inhibitors of plasma kinin formation. Nature (Lond.) 194, 689.CrossRefGoogle Scholar
  12. 12.
    Croxatto, H. and Cruzatt, H. (1969). Ineffectiveness of carboxypeptidase B in inhibiting the pressor effect of incubated human plasma. Experientia. 25: 59–60.PubMedCrossRefGoogle Scholar
  13. 13.
    Croxatto, H., Roblero, J. and Ossio, M. (1965) Vasopressor substances formed in the blood serum by incubation at 38°C. at normal pH. Arch. med. Exp. ( Chile ) 2: 55–62.Google Scholar
  14. 14.
    Kenner, Th. and Waldhausl, W. (1964). A nondialysable, heat-stabile, hypertensive substance in the serum of rats. Nature 204, 581–582.PubMedCrossRefGoogle Scholar
  15. 15.
    Roblero, J. and Croxatto, H. (1967). Vasoactive substances formed in blood serum by incubation at 37°C. at normal pH. In: International Symposium on Vasoactive Polypeptides; Bradykinin and Related Kinins. Ribeirão Prêto, August 1966; Eds. Rocha e Silva, M. and Rothchild, H. A. pp 119125. Sao Paulo: Soc: Bras. Farmacologia e Terapéutica Experimental.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Désirée Armstrong
    • 1
    • 2
  • H. Croxatto
    • 1
    • 2
  • J. Roblero
    • 1
    • 2
  1. 1.Department of PharmacologyThe Middlesex Hospital Medical School, University of LondonEngland
  2. 2.Laboratorio de FisiologiaUniversidad Catolica de ChileSantiagoChile

Personalised recommendations