Release of Serotonin in Man Induced by Some Polypeptides
The common appearance of serotonin and bradykinin in some clinical syndromes, as in carcinoid, dumping syndrome and migraine, has raised the question whether the increase in one could be produced by an increase in the other or whether they are independent. It is known from the study of Hilton et al. (1956) that serotonin may increase the plasma content of catecholamines, and this in turn may liberate bradykinin-forming enzyme from the salivary gland. On the other hand, the possible release of serotonin through bradykinin seems not to be well established. We tried to study this problem by giving intravenous infusions of bradykinin and of another peptide, angiotensin, to man and by estimating the excretion of the metabolites of serotonin in urine.
KeywordsSalivary Gland Primary Hyperaldosteronism Renovascular Hypertension Rapid Intravenous Injection Slow Intravenous Infusion
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