Plasmatic Kininogen in Acute Hepatitis and in Liver Cirrhosis
The first researches on the kininogen level in plasma indicated that the probable site of synthesis of this precursor was the liver (Diniz et al., 1961; Diniz and Carvalho, 1963). This observation was based upon the fact that, being the liver the main site of the protein synthesis, it was natural to beleive that also the polypeptide sequence of kininogen was realized in this organ. We still lack, however, of direct evidences of this situation in man; as regards to the animal, Bryan et al. (1971) were able to prove in the rat that the synthesis of kininogen occurs in the liver. However, in man we still lack of evident proofs. Diniz et al. (1961, 1963) noticed that in serious damage of the hepatic functions, namely cirrhosis, the plasmatic kininogen resulted to be depressed.
KeywordsLiver Cirrhosis Conventional Therapy Acute Hepatitis Probable Site Hepatic Cirrhosis
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