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Vasopeptides pp 453-456 | Cite as

Plasmatic Kininogen in Acute Hepatitis and in Liver Cirrhosis

  • P. L. Del Bianco
  • M. Fanciullacci
  • G. Franchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)

Abstract

The first researches on the kininogen level in plasma indicated that the probable site of synthesis of this precursor was the liver (Diniz et al., 1961; Diniz and Carvalho, 1963). This observation was based upon the fact that, being the liver the main site of the protein synthesis, it was natural to beleive that also the polypeptide sequence of kininogen was realized in this organ. We still lack, however, of direct evidences of this situation in man; as regards to the animal, Bryan et al. (1971) were able to prove in the rat that the synthesis of kininogen occurs in the liver. However, in man we still lack of evident proofs. Diniz et al. (1961, 1963) noticed that in serious damage of the hepatic functions, namely cirrhosis, the plasmatic kininogen resulted to be depressed.

Keywords

Liver Cirrhosis Conventional Therapy Acute Hepatitis Probable Site Hepatic Cirrhosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bryan F.T., Ryan J.W. and Nimeyer R.: “Bradykininogen synthesis by liver”. This SymposiumGoogle Scholar
  2. Diniz. C.R., Carvalho I.F., Ryan J. and Rocha e Silva M.: “A micromethod for the determination of bradykininogen in blood plasma”. Nature (Lond.) 192, 1194, 1961.Google Scholar
  3. Diniz C.R. and Carvalho I.F.: “A micromethod of estimation of bradykininogen under several physiological and pathological conditions”. Ann. N.Y. Acad. Sci. 104, 77, 1963.PubMedCrossRefGoogle Scholar
  4. Panuccio P., Cresci F. and Viroli L.: “Hypotensive peptides”. Proc.Int. Symposium. E.G.Erdös, N.Back and F.Sicuteri Ed. Springer Verlag,N.Y. 1966, p. 534 (Discussion).Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • P. L. Del Bianco
    • 1
  • M. Fanciullacci
    • 1
  • G. Franchi
    • 1
  1. 1.Department of Clinical PharmacologyUniversity of FlorenceFlorenceItaly

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