Vasopeptides pp 435-443 | Cite as

Role of Vasoactive Peptides and Local Hormones in Experimental Cold Injury in Monkeys

  • R. B. Arora
  • S. K. Gupta
  • K. Rajanna
  • H. H. Siddiqui
  • M. Tariq
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


Progress in the knowledge of frostbite has been slow, owing to the scarcity of cases in peace time and the difficulty of planned study during war. Frostbite is a condition of local cold injury resulting from exposure to cold well below the freezing temperature. Vasoconstriction is the first reaction to the cold exposure (Lewis, 1941). Initially arterioles and small arteries are involved and ultimately the whole vascular tree is affected (Sullivan and Towle, 1957). The spasm in arterioles and venules of the affected part and adjoining areas slow down the blood flow (Kulka et al, 1958). If the stasis persists thrombus formation occurs, leading to anoxia and death of the tissue (Zweifach, 1963). These changes are supposed to be brought about partly by the direct action of cold on the tissue and partly by the release of chemical mediators (Rocha E Silva, 1964). Therefore, the role of these mediators have been studied in monkeys after experimental cold injury. Since the inactivating enzymes play an important role in control of the level of these local hormones, the levels of bradykinase, angiotensinase and histaminase have also been estimated.


Histamine Level Cold Injury Vasoactive Peptide Plasma Histamine Level Local Hormone 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • R. B. Arora
    • 1
  • S. K. Gupta
    • 1
  • K. Rajanna
    • 1
  • H. H. Siddiqui
    • 1
  • M. Tariq
    • 1
  1. 1.Department of PharmacologyAll-India Institute of Medical SciencesAnsari Nagar, New Delhi-16India

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