Bradykininogen Synthesis by Liver

  • F. T. Bryan
  • J. W. Ryan
  • R. S. Niemeyer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


Kininogen disappears from peripheral blood after hepatectomy or intoxication with carbon tetrachloride (1), a point that suggests that kininogen is synthesized by the liver. In the present study we have tested this possibility by perfusing the isolated liver with Krebs-Henseleit solution containing 14C-arginine and 14C-proline. The radioactive protein formed by the isolated liver reacts with a specific kininogenase (2) to produce a radioactive peptide indistinguishable from bradykinin. We interpret our data to mean that kininogen is synthesized by the liver.


Liver Perfusate Howard Hughes Medical Institute Hepatic Protein Synthesis Radioactive Protein Plasma Kininoge 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • F. T. Bryan
    • 1
  • J. W. Ryan
    • 1
  • R. S. Niemeyer
    • 1
  1. 1.Departments of Medicine and SurgeryUniversity of Miami School of Medicine and the Howard Hughes Medical InstituteMiamiUSA

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