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Vasopeptides pp 381-390 | Cite as

Studies on the Mechanism of Kinin Release Induced by Antilymphocyte Globulin

  • John Bradley
  • Alfred Cuschieri
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)

Abstract

Antilymphocyte serum or globulin (ALG) has been used in man and animals as a means of immunosuppression in the transplantation of allogeneic tissue. Among the side effects encountered during its administration are fever, hypotensive episodes and anaphylactoid reactions. Kashiwagi et al (1968) found that the anaphylactoid reactions were characteristic: within 1–30 minutes of injection the patients became anxious and complained of low back pain. Nausea and involuntary defaecation accompanied cyanosis and hypotension. Recovery took place within 90 minutes. These reactions have been attributed to the presence of pre-formed reaginic or precipitating antibodies in the recipient against the donor of the ALG, or to the presence of aggregated gammaglobulin in the ALG.

Keywords

Horse Serum Anaphylactoid Reaction Kinin Level Passive Cutaneous Anaphylaxis Autologous Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Barandun, S., Kistler, P., Jeunet, F., and Isliker, H. (1962) Vox Sang. 7, 157.PubMedCrossRefGoogle Scholar
  2. 2.
    Beraldo, W.T., Am. J. Physiol. (1950) 163, 283.PubMedGoogle Scholar
  3. 3.
    Boreham, P.F.L., and Goodwin, L.G. ‘Bradykinin and Related Kinins’ edited by F. Sicuteri, M. Rocha e Silva and N. Back, p. 539, New York - London, 1970.Google Scholar
  4. 4.
    Brocklehurst, W.E. and Lahiri, G.C., J. Physiol. (1962) 160, 15.Google Scholar
  5. 5.
    Coombs, R.R.A. and Gell, P.G.H. in Clinical Aspects of Immunology, 2nd Edition, Ch. 20, p. 575, Ed: Gell and Coombs, Blackwell, Oxford, 1968.Google Scholar
  6. 6.
    Diniz, L.R. and Carvallho, J.F., Ann. N.Y. Acad. Sci., (1963), 104, 77.PubMedCrossRefGoogle Scholar
  7. 7.
    Greenbaum, L.M. and Kim, K.S. Brit. J. Pharmacol. (1967), 29, 238.Google Scholar
  8. 8.
    Kashiwagi, N., Brantigan, C.O., Brett Schneider, L., Groth, C.G., and Starzl, T.E. Annals of Int. Med. (1968), 68, 275.Google Scholar
  9. 9.
    Layton, L.L., Yamanaka, E., Greene, F.C. and Perlman, N.F., Int. Arch. Allergy (1963) 23, 87.PubMedCrossRefGoogle Scholar
  10. 10.
    Mongar, J.L. and Perera, B.A.V. J. Physiol. (1962) 162, 70.Google Scholar
  11. 11.
    Movat, H.Z. and Di Lorenzo, N.L. Lab. Invest. (1968) 19, 187.Google Scholar
  12. 12.
    Movat, H.Z., Di Lorenzo, N.L. and Treloar, M.P. Lab. Invest. (1968) 19, 201.Google Scholar
  13. 13.
    Najarian, J.S. and Simmons, R.L. New Eng. J. Med. (1971) 285, 158.Google Scholar
  14. 14.
    Talamo, R.C., Haber, E., and Austen, K.F. J. Lab. Clin. Med., (1969) 74, 816.Google Scholar
  15. 15.
    Webster, M.E. and Clark, W.R. Am. J. Physiol. (1959) 197, 406.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • John Bradley
    • 1
  • Alfred Cuschieri
    • 1
  1. 1.Departments of Medicine and SurgeryUniversity of LiverpoolUK

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