Vasopeptides pp 381-390 | Cite as

Studies on the Mechanism of Kinin Release Induced by Antilymphocyte Globulin

  • John Bradley
  • Alfred Cuschieri
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


Antilymphocyte serum or globulin (ALG) has been used in man and animals as a means of immunosuppression in the transplantation of allogeneic tissue. Among the side effects encountered during its administration are fever, hypotensive episodes and anaphylactoid reactions. Kashiwagi et al (1968) found that the anaphylactoid reactions were characteristic: within 1–30 minutes of injection the patients became anxious and complained of low back pain. Nausea and involuntary defaecation accompanied cyanosis and hypotension. Recovery took place within 90 minutes. These reactions have been attributed to the presence of pre-formed reaginic or precipitating antibodies in the recipient against the donor of the ALG, or to the presence of aggregated gammaglobulin in the ALG.


Horse Serum Anaphylactoid Reaction Kinin Level Passive Cutaneous Anaphylaxis Autologous Plasma 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • John Bradley
    • 1
  • Alfred Cuschieri
    • 1
  1. 1.Departments of Medicine and SurgeryUniversity of LiverpoolUK

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