Vasopeptides pp 337-346 | Cite as

Comparative Action of Peptides on the Gall Bladder and the Sphincter of Oddi

  • F. Lembeck
  • H. Juan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


Several peptides contract the gall bladder in the guinea pig, cat, dog, chicken and in man: Cholecystokinin-Pankreozymin (CCK-PZ) (Ivy and Oldberg, 1928) and its C-terminal octapeptide (CTO) (Mutt and Jorpes,1968; Rubin et al., 1969; Ondetti et al., 1970; Hedner,1970), caerulein (Bertaccini et al., 1968, 1969, 1970; Agosti et al., 1971), substance P (SP) and a physalaemin-like octapeptide (P 30) (Starke et al., 1968). A concommitant relaxation of the sphincter of Oddi by CCK-PZ and CTO was reported in the cat (Hedner, 1970), and by caerulein in the guinea pig (Bertaccini et al., 1968), dog and in man (Lin and Spray, 1969), but a spasmogenic effect on the isolated ductus choledochus of the calf (Agosti et al., 1971).


Gall Bladder Biliary System Threshold Dose Vertical Tube Ductus Choledochus 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • F. Lembeck
    • 1
  • H. Juan
    • 1
  1. 1.Institute of PharmacologyUniversity of GrazAustria

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