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Vasopeptides pp 317-323 | Cite as

Effect of Kinins and of Kinin-Releasing Enzymes on Rat Mast Cells

  • A. M. Rothschild
  • M. P. O. Antonio
  • J. J. Dias
  • A. Castania
  • L. C. Neves
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)

Abstract

When occurring at the mast cell, the major outcome of the antigen-antibody reaction is the release of histamine (review by Mote, 1966). The formation of bradykinin as a consequence of the antigen antibody reaction in vivo or in vitro has been described (Beraldo, 1950; Rothschild, 1968). Trypsin has been shown to release kinin (review by Habermann, 1970); its histamine releasing activity has been reviewed by Rocha e Silva (1955). Chymotrypsin has been describ ed as a kinin releasing agent (Rocha e Silva, 1970), which is also able to stimulate rat mast cell degranulation, an event associated with histamine release (Uvnäs and Antonsson, 1963; Saeki, 1964). A chymotrypsin-like enzyme is activated during antigen-antibody reactions at the mast cell; inhibiton of this enzyme leads to blockade of histamine release (Becker and Austen, 1966). These results seemed to warrant a search for a correlation between bradykinin formation and histamine release. This has been sought for in the present study, in which the effect of kinins, of trypsin and of chymotrypsin on histamine release from isolated rat peritoneal fluid mast cells has been examined.

Keywords

Mast Cell Ethyl Ester Histamine Release Esterolytic Activity Isolate Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Refermes

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • A. M. Rothschild
    • 1
  • M. P. O. Antonio
    • 1
  • J. J. Dias
    • 1
  • A. Castania
    • 1
  • L. C. Neves
    • 1
  1. 1.Department of PharmacologySchool of Medicine of Ribeirão PrêtoBrazil

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