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Vasopeptides pp 309-316 | Cite as

Comparative Actions of Kinins of Increasing Molecular Weight on Smooth Muscle, Blood Pressure and Vascular Permeability

  • M. Rocha e Silva
  • Marina L. Reis
  • Lyioko Okino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)

Abstract

It has been well established in the literature (Stürmer and Ber de, 1962; Schröder and Lübke, 1966; Stewart and Woolley, 1967) that the pharmacological actions of bradykinin and its two known natural derivatives (Lys Bk and Met-Lys-Bk) change if we prolong the chain of amino acids, at the NH2-terminal, according to the biological preparation utilized, as well as to their resistance to destruction by kininases. For instance, the activity on smooth muscle falls to one half with Lys Bk and to one third with Met-ys-Bk. On the other hand, as far as the actions upon blood pressure are concerned, the activity increases by about the same proportion in the reverse direction, in such a way that we have the following sequences:
  • Rat uterus: Bk > Lys-Bk > Met-Lys-Bk.

    Guinea pig ileum: Bic > Lys-Bk > Met-Lys-Bk.

    Rabbit B.P.: Met.-Lys-Bk) Lys-Bk > Bk.

Keywords

Vascular Permeability Discrimination Index Permeability Factor Cellulose Sulfa Biological Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • M. Rocha e Silva
    • 1
  • Marina L. Reis
    • 1
  • Lyioko Okino
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUSPRibeirão Prêto, São PauloBrazil

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