Rat Intestinal Kallikrein
Aqueous extracts of mammalian gut wall were shown by Werle and his colleagues (1960) to contain a trypsin-activated hypo-:tensive activity. They called this activity a kallikrein although they presented no direct evidence that kinin release was involved. Ammdsen and Nustad (1965) noted that simple saline extracts from intestinal activity. They called this activity a kallikrein although they presented no direct evidence that kinin release was involved. Amundsen and mucosae of rats and rabbits released a smooth muscle stimulant from treated human plasma. However, they did not characterize either the smooth muscle stimulant or the nature of its release. In a recent review, Webster (1970) has suggested that the activities involved in these two studies were not, in fact, kallikreins, but other “endogenous proteases”.
KeywordsHydrolysis Toluene Polypeptide Ketone Arginine
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