Vasopeptides pp 267-276 | Cite as

Pulmonary Endothelial Cells and the Metabolism of Adenine. Nucleotides, Kinins and Angiotensin I

  • Una Smith
  • J. W. Ryan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


As indicated in previous publications (1–9) and as revealed in the preceding paper (10), it is likely that circulating adenine nucleotides, kinins and angiotensin I are metabolized by enzymes of the luminal surface of the pulmonary endothelium. One of the nucleotides, namely adenosine-5’-monophosphate (AMP), is metabolized by enzymes of caveolae intracellulares open to the vascular lumen (7–9). This enzymic activity is not peculiar to those caveolae open to the vascular lumen, as one can show by reactions performed on fixed blocks of tissue (5,6) that other caveolae and intracellular vesicles are capable of degrading nucleotides. However, in the case of metabolism of circulating nucleotides it appears that only those caveolae open to the lumen have access to the substrate.


Adenine Nucleotide Luminal Surface Vasoactive Substance Vascular Lumen Lead Phosphate 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Una Smith
    • 1
  • J. W. Ryan
    • 1
  1. 1.Department of MedicineUniversity of Miami and the Howard Hughes Medical InstituteMiamiUSA

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