Radioimmunoassay of Circulating Blood Kinin Levels

  • M. L. Mashford
  • M. L. Roberts
  • G. W. Johnston
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


Previous estimates of the level of circulating kinins in man have ranged widely from undetectable, (1) to a mean level of about a quarter of a ng/ml (2) to levels in the μg/ml (3) range. Some workers have questioned that there is a normal level of circulating kinin and view the small amounts found as being artefacts produced by activation of plasma kininogenase during collection. Another view is that kinins are produced extravascularly and that blood levels are likely to be irrelevant to normal or abnormal function except in such rare situations as the carcinoid syndrome in which kallikrein is released by the tumour masses and produces kinins in the blood itself. Certainly the central role of tissues and particularly the lung, (4) in clearance argues against the arterial blood kinin level being of great functional significance. Nevertheless, a reliable method of measuring blood levels would be welcome since they may give an indication, admittedly considerably damped, of what was proceeding in the tissues whence the blood drained.


Carcinoid Syndrome Coated Charcoal Blood sampIes Human Gamma Globulin Measure Blood Level 


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • M. L. Mashford
    • 1
  • M. L. Roberts
    • 1
  • G. W. Johnston
    • 1
  1. 1.Departments of Pharmacology and Medicine, (Austin Hospital)University of MelbourneParkvilleAustralia

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