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Vasopeptides pp 221-231 | Cite as

Fine Structure of Secretory Granules in Mammalian Submaxillary Glands

  • Gundula Dorey
  • K. D. Bhoola
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)

Abstract

In exocrine glands macromolecules synthesized for secretion are mainly segregated and sequestered in specific organelles within cells. It is now established that the serine protease kallikrein, and the digestive enzyme amylase, are stored intracellularly in membrane-bounded organelles. Trypsin-like enzymes isolated from the rat submaxillary gland are probably similarly stored in granules. It is evident from this study and those of Shackleford and coworkers (see Shackleford & Wilborn, 1968) that mammalian sub-maxillary glands show marked differences in the morphology of the various acinar and duct cells and the granules which contain secretory enzymes and other macromolecules. The question therefore arises as to which granules within which cells contain kallikrein, trypsin-like enzymes and amylase. The precise cellular location of the granules which contain the secretory enzymes may provide some insight into the possible physiological role of submaxillary kallikrein and the trypsin-like proteases.

Keywords

Acinar Cell Submaxillary Gland Duct Cell Intercalate Duct Striate Duct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Gundula Dorey
    • 1
  • K. D. Bhoola
    • 1
  1. 1.Department of PharmacologyUniversity of Bristol Medical SchoolBristolUK

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