Inhibition by Sulfhydryl Reagents of the Effects of Bradykinin, Arachidonic Acid and “Slow Reacting Substance C”
Acidic antiinflammatory agents inhibit bronchoconstriction due to bradykinin (1), arachidonic acid (AA) (2), and Slow Reacting Substance C (SRS-C) (3), and suppress completely the hypotension due to SRS-C in the rabbit and in the dog (3, 4) as well as the secondary hypotension bradykinin evokes in the rabbit (5) and in the guinea-pig (6). It has been proposed that a new mediator, called “Rabbit Aorta Contracting Substance” (RCS), which is released by anaphylaxis, bradykinin, Slow Reacting Substance A (SRS-A) (7), SRS-C and AA (8), is involved in those effects of the mentioned agonists which are blocked by nonsteroidal antiinflammatory agents (7, 8); RCS release from the guinea-pig lung is blocked by phenylbutazone — like drugs.
KeywordsArachidonic Acid Sodium Cromoglycate Rabbit Aorta Propranolol Hydrochloride Sulfhydryl Reagent
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