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Vasopeptides pp 141-148 | Cite as

Dissociation of Oedema Provoking Factor of Agkistrodon Piscivorus Venom from Kininogenase

  • N. Bhargava
  • B. B. Vargaftig
  • C. J. de Vos
  • I. L. Bonta
  • T. Tijs
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)

Abstract

The development of a method for measuring the hemorrhagic activity qualitatively as well as quantitatively by Bonta et al. (1) made it possible to characterise the hemorrhagic factors of some venoms. These factors were revealed to be basic polypeptides of less than 10,000 molecular weight. Since hemorrhages are known to accompany a variety of allergic inflammations and since it has also been found that oestriol succinate inhibits the hemorrhages (2) as well as the cobra venom induced rat paw oedema (3,9), it seemed worthwhile investigating whether some venom fractions which induce pulmonary hemorrhages are able to induce oedema. In addition some chemical and pharmacological properties of these fractions have been investigated.

Keywords

Esterase Activity Dansyl Chloride Crude Venom Cobra Venom Hemorrhagic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • N. Bhargava
    • 1
    • 2
    • 3
  • B. B. Vargaftig
    • 1
    • 2
    • 3
  • C. J. de Vos
    • 1
    • 2
    • 3
  • I. L. Bonta
    • 1
    • 2
    • 3
  • T. Tijs
    • 1
    • 2
    • 3
  1. 1.Research Laboratories of N.V. OrganonOssThe Netherlands
  2. 2.Organon S.A.Eragny-sur-EpteFrance
  3. 3.Department of PharmacologyMedical Faculty RotterdamThe Netherlands

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