Vasopeptides pp 129-134 | Cite as

The Role of Plasmin in the Activation of the Kinin System

  • Clement E. Burrowes
  • Henry Z. Movat
  • Mary J. Soltay
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


Some time ago plasmin was believed to be the main kinin-forming enzyme (1,2). The studies of several investigators indicated that plasmin formed kinin from kininogen at a relatively slow rate (2,3,4,5). However, when added to fresh plasma, plasmin induces rapid generation of kinin and this was interpreted to mean that plasmin activated prekallikrein and kallikrein induced the rapid formation of kinin (4,6,7, 8).


Fresh Plasma Polyacrylamide Electrophoresis Kinin System Hageman Factor Plasma Kinin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. (1).
    Beraldo, W.T.: Formation of bradykinin in anaphylactic and peptone shock. Amer. J. Physiol., 171: 371, 1950.Google Scholar
  2. (2).
    Lewis, G. P.: Formation of plasma kinins by plasmin. J. Physiol., 140: 285, 1958.PubMedGoogle Scholar
  3. (3).
    Ratnoff, O. D.: Increased vascular permeability induced by human plasmin. J.Exp.Med., 122: 905, 1965.PubMedCrossRefGoogle Scholar
  4. (4).
    Back, N.: Fibrinolysin system and vasoactive kinins. Fed. Proc., 25: 77, 1966.PubMedGoogle Scholar
  5. (5).
    Henriques, O. B., Lavras, A. A.C., Fichman, M., and Picarelli, Z. P.: Plasma enzymes that release kinins. Biochem. Pharmacol., 15: 31, 1966.PubMedCrossRefGoogle Scholar
  6. (6).
    Webster, M.E., and Pierce, J.V.: Studies on plasma kallikrein and its relationship to plasmin. J. Pharmacol.exp.Therap., 130: 484, 1960.Google Scholar
  7. (7).
    Vogt, W.: Kinin formation by plasmin: An indirect process mediated by activation of kallikrein. J. Physiol., 170: 153, 1964.PubMedGoogle Scholar
  8. (8).
    Seidel, G., St’úcker, H. -U., and Vogt, W.: The role of plasmin for kinin-formation in human plasma. Naunyn-Schmiedebergs Arch. Pharmakol., 264: 305, 1969.PubMedCrossRefGoogle Scholar
  9. (9).
    Burrowes, C.E., Movat, H.Z., and Soltay, M.J.: The kinin system of human plasma. VI. The action of plasmin. Proc.Soc.Exp. Biol. Med., 139: Dec. 1971, in press.Google Scholar
  10. (10).
    Soltay, M.J., Movat, H.Z., and Özge Anwar, A.H.: The kinin system of human plasma. V. The probable derivation of prekallikrein activator from activated Hageman factor (XIIa). Proc.Soc. Exp. Biol. Med., 139: Dec. 1971, in press.Google Scholar
  11. (11).
    Deutsch, D. G., and Mertz, E.T.: Plasminogen: Purification from human plasma by affinity chromatography. Science, 170: 1095, 1970.PubMedCrossRefGoogle Scholar
  12. (12).
    Movat, H.Z., Soltay, M.J., Fuller, P.J. and Özge Anwar, A. H.: The relationship between the plasma kinin-system and the contact phase of blood-coagulation in man. In Vasoactive Polypeptides Back, N., and Sicuteri, F., eds., Plenum Press, New York and London, in press.Google Scholar
  13. (13).
    Movat, H.Z., and Özge Anwar, A.H.: The interrelationship between the kinin and blood-clotting systems. Fed. Proc., 30: 451, 1971.Google Scholar
  14. (14).
    Özge Anwar, A. H., Movat, H. Z., and Scott, J. G.: The kinin system of human plasma. IV. The interrelationship between the contact phase of blood-coagulation and the plasma kinin system in man, Thromb. Diath. Haemorrh., in press.Google Scholar
  15. (15).
    Kaplan, A.P., and Austen, K.F.: A prealbumin activator of prekallikrein. Il. Derivation of activators of prekallikrein from active Hageman factor by digestion with plasmin. J.Exp.Med 133: 696, 1971.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Clement E. Burrowes
    • 1
  • Henry Z. Movat
    • 1
  • Mary J. Soltay
    • 1
  1. 1.Division of Experimental Pathology and Institute of ImmunologyUniversity of TorontoTorontoCanada

Personalised recommendations