An Alternative Scheme of Kinin Formation during Contact Activation of Human Plasma
Among the various reactions that lead to kinin formation those are of particular interest which proceed by factors endogenous to plasma, as these represent the most readily available natural kinin forming system. As is well-known plasma contains simultaneously prekininogenases, activators and substrates. Armstrong, Keele, Jepson and Stewart (1954) found that the kinin forming system in plasma can be triggered by contact with foreign surfaces, e.g. collagen or glass, and Margolis (1960) demonstrated that it is Hageman Factor which is activated by absorption to these surfaces, and which in turn activates a kininogenase (“component A”).
KeywordsHuman Plasma Contact Activation Kinin Activity Quartz Powder Plasma Kallikrein
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