Abstract
Among the various reactions that lead to kinin formation those are of particular interest which proceed by factors endogenous to plasma, as these represent the most readily available natural kinin forming system. As is well-known plasma contains simultaneously prekininogenases, activators and substrates. Armstrong, Keele, Jepson and Stewart (1954) found that the kinin forming system in plasma can be triggered by contact with foreign surfaces, e.g. collagen or glass, and Margolis (1960) demonstrated that it is Hageman Factor which is activated by absorption to these surfaces, and which in turn activates a kininogenase (“component A”).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Armstrong, D., Keele, C.A., Jepson, J.B., Stewart,J.W.: Development of pain-producing substance in human plasma. Nature (Lond.) 174, 791 (1954).
Frey, E.K., Kraut, H., Werle, E.: Das Kallikrein-Kininsystem und seine Inhibitoren. Enke-Verlag Stuttgart, 1968 p. 12.
Jahrreis, R., Habermann, E.: On the endogenous mechanism of kinin release. I. Attempts at discrimi-nating kallikreins. Naunyn-Schmiedebergs Arch. Pharmak. 269, 85 (1971).
Margolis, J.: The mode of action of Hageman Factor in the release of plasma kinin. J. Physiol. (Lond.) 151, 238 (1960).
Seidel, G., Stucker, H.U., Vogt, W.: Significance of direct and indirect kinin formation by plasmin in human plasma. Biochem. Pharmacol. in print, 1971.
Vogt, W.: Demonstration of the presence of two separate kinin forming systems in human and other plasma. In: Hypotensive peptides, p.185, ed. by E.G.Erdös, N.Back and F. Sicuteri. Berlin - Heidelberg -New York: Springer 1966.
Werle, E., Vogel, R.: Über die Kallikreinausscheidung im Harn nach experimenteller Nierenschädigung. Arch. int. Pharmacodyn. 126, 171 (1960).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1972 Plenum Press, New York
About this chapter
Cite this chapter
Vogt, W., Schlaeger, M., Seidel, G., Stücker, HU. (1972). An Alternative Scheme of Kinin Formation during Contact Activation of Human Plasma. In: Back, N., Sicuteri, F. (eds) Vasopeptides. Advances in Experimental Medicine and Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7439-8_13
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7439-8_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7441-1
Online ISBN: 978-1-4684-7439-8
eBook Packages: Springer Book Archive