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Vasopeptides pp 103-108 | Cite as

An Alternative Scheme of Kinin Formation during Contact Activation of Human Plasma

  • W. Vogt
  • M. Schlaeger
  • G. Seidel
  • H.-U. Stücker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)

Abstract

Among the various reactions that lead to kinin formation those are of particular interest which proceed by factors endogenous to plasma, as these represent the most readily available natural kinin forming system. As is well-known plasma contains simultaneously prekininogenases, activators and substrates. Armstrong, Keele, Jepson and Stewart (1954) found that the kinin forming system in plasma can be triggered by contact with foreign surfaces, e.g. collagen or glass, and Margolis (1960) demonstrated that it is Hageman Factor which is activated by absorption to these surfaces, and which in turn activates a kininogenase (“component A”).

Keywords

Human Plasma Contact Activation Kinin Activity Quartz Powder Plasma Kallikrein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Armstrong, D., Keele, C.A., Jepson, J.B., Stewart,J.W.: Development of pain-producing substance in human plasma. Nature (Lond.) 174, 791 (1954).CrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • W. Vogt
    • 1
  • M. Schlaeger
    • 1
  • G. Seidel
    • 1
  • H.-U. Stücker
    • 1
  1. 1.Dept. of Biochem. PharmacologyMax-Planck-Institut für experimentelle Medizin34 GöttingenGermany

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