The Presence of a Smooth Muscle Contracting and Bradykinin Potentiating Factor in Plasma

  • Antti Louhija
  • Risto Sipilä
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 21)


The final proof of the activation of the kininsystem is the demonstration of the liberation of free kinin into the blood or other biological fluids. The current methods for free kinin determination include rapid denaturation of the blood proteins (including kallikreins, kininogens and kininases), purification of the extracts to eliminate active substances interfering with the assay, concentration of the extracts, and finally the assay for which smooth muscle has mostly been used.


Blood Extract Purrent Method Blood sampIes Free Kinin Uterus Contracting 


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Antti Louhija
    • 1
  • Risto Sipilä
    • 1
  1. 1.The Wihuri Research InstituteHelsinkiFinland

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