Protein Components which Relate to the Kinin Releasing System in Bovine Plasma
Blood plasma contains several discrete systems consisting of the sequential conversion of proenzymes into active enzymes, in which their activations lead to a hypotension due to the liberation of vasoactive polypeptide termed kinin, and to thrombosis and hemorrhage due to the formation and lysis of fibrin clot. From physiological point of view, it is of interest how is the kallikrein-kinin system to be concerted with the other enzyme systems, such as blood coagulation and fibrinolysis. Recently, it was suggested that Hageman factor, which is known to have triggering action for the intrinsic coagulation and fibrinolysis systems, also pull the trigger for the activation of kallikreinkinin system. To clarify the above relations, it is extremely important to isolate the pure components, which concern to the liberation of kinin, and to elucidate their interrelations, reconstructing the kinin liberating systems in vitro.
KeywordsEllagic Acid Bovine Plasma High Molecular Weight Kininogen Active Kallikrein Hageman Factor
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