Oxygen Consumption Rate of Tumour Cells as a Function of their Proliferative Status

  • S. Walenta
  • W. Mueller-Klieser
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 215)


The oxygen consumption rate \(\left( \dot{Q}{{O}_{2}} \right)\) of EMT6/Ro-cells cultured as monolayers was investigated as a function of their proliferative status. The transition of these cells from the exponential to the plateau growth phase was associated with a continuous decrease in \(\dot{Q}{{O}_{2}}\) per single cell. This decrease can partially be attributed to a corresponding decline in cellular volume. In addition, the \(\dot{Q}{{O}_{2}}\) per cell volume was also reduced during the passage of the cells through the growth phase described. The results lead to the conclusion that a reduction in cellular volume and factors which are still unknown may contribute to the metabolic changes observed.


Cell Volume Oxygen Consumption Rate Plateau Phase Proliferative Status Injection Fluid 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. Walenta
    • 1
  • W. Mueller-Klieser
    • 1
  1. 1.Department of Applied PhysiologyUniversity of MainzMainzGermany

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