Abstract
Our aerobic existence provides overwhelming energetic advantages over that of anaerobes, the oxidation of glucose yielding approximately 15 times more energy than the anaerobic conversion of glucose to lactate. However, the four electron reduction of oxygen to water necessarily progresses through toxic intermediate free radical species. All aerobically respiring cells are consequently under constant threat of oxidation from these highly reactive free radical intermediates (Fridovich, 1982).
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References
Bartosz, G., Tannert, Ch., Fried, R. and Leyko, W. (1978). Superoxide dismutase activity decreases during erythrocyte aging. Experientia, 34, 1464.
Beutler, E. (1975). Red Cell Metabolism: a Manual of Biochemical Techniques. Grune and Stratton, New York.
Bieri, J.B. and Anderson, A.A. (1960). Peroxidation of lipids in tissue homogenates as related to vitamin E. Arch. Biochem. Biophys. 90, 105–110.
Buege, J.A. and Aust, S.D. (1978). Microsomal lipid peroxidation. In: Methods in Enzymology, 52, Academic Press, New York, pp. 302–310.
Clark, J.M. and Lambertsen, C.J. (1971). Pulmonary oxygen toxicity-a review. Pharmac. Rev. 23, 37–133.
Crapo, J.D., McCord, J.M. and Fridovich, I. (1978). Preparation and assay of superoxide dismutases. In: Methods in Enzymology, 53, Academic Press, New York, pp. 382–393.
Fisher, A.B. and Forman, H.J. (1985). Oxygen utilization and toxicity in the lungs. In: Handbook of Physiology, Section 3: Respiration, Volume 1. Eds Fishman, A.P. and Fisher, A.B., American Physiological Society, Bethesda, pp. 231–254.
Fridovich, I. (1982). Chemical and biological aspects of the superoxide radical and of superoxide dismutase. In: Membranes, Molecules, Toxins and Cells. Eds Bloch, K., Bolis, L. and Tosteson, D.C., PSG Inc., Boston, pp. 105–122.
Hansen, T.N., Hazinski, T.A. and Bland, R.D. (1982). Vitamin E does not prevent oxygen induced lung injury in newborn lambs. Pediatr. Res. 16, 583–587.
Jamieson, D. and Van Den Brenk, H.A.S. (1964). The effects of antioxidants on high pressure oxygen toxicity. Biochem. Pharmac. 13, 159–164.
Lowry, O.H., Rosenbrough, N.J., Farr, A.L. and Randall, R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265–275.
Matzen, R.N. (1957). Effect of vitamin C and hydrocortisone on the pulmonary edema produced by ozone in mice. J. Appl. Physiol. 11, 105–109.
Nitowsky, H.M. (1956). Tocopherol deficiency in infants and children: II. Plasma tocopherol and erythrocyte haemolysis in hydrogen peroxide. Am. J. Dis. Child. 92, 164–174.
Sass, M.D., Vorsanger, E. and Spear, P.W. (1964). Enzyme activity as an indicator of red cell age. Clin. Chim. Acta, 10, 21–26.
Slater, T.F. (1972). Free Radical Mechanisms in Tissue Injury. Pion, London.
Turrens, J.F., Freeman, B.A., and Crapo, J.D.. (1982). Hyperoxia increases hydrogen peroxide release by lung mitochondria and microsomes. Arch. Biochem. Biophys. 217, 411–421
Turrens, J.F., Freeman, B.A., Levitt, J.G. and Crapo, J.D.. (1982). The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch. Biochem. Biophys. 217, 401–410.
Wender, D.F., Thulin, G.E., Smith, G.J.W. and Warshaw, J.B. (1981). Vitamin E affects lung biochemical and morphological response to hyperoxia in the newborn rabbit. Pediatr. Res. 15, 262–268.
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© 1987 Plenum Press, New York
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Webster, N.R., Toothill, C. (1987). Effect of Antioxidants on the Biochemical Response in the Oxygen-Exposed Rat. In: Silver, I.A., Silver, A. (eds) Oxygen Transport to Tissue IX. Advances in Experimental Medicine and Biology, vol 215. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7433-6_44
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DOI: https://doi.org/10.1007/978-1-4684-7433-6_44
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