Effect of Antioxidants on the Biochemical Response in the Oxygen-Exposed Rat

  • N. R. Webster
  • C. Toothill
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 215)


Our aerobic existence provides overwhelming energetic advantages over that of anaerobes, the oxidation of glucose yielding approximately 15 times more energy than the anaerobic conversion of glucose to lactate. However, the four electron reduction of oxygen to water necessarily progresses through toxic intermediate free radical species. All aerobically respiring cells are consequently under constant threat of oxidation from these highly reactive free radical intermediates (Fridovich, 1982).


Reduce Glutathione Treatment Figure Oxygen Toxicity Oxygen Control Newborn Rabbit 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • N. R. Webster
    • 1
  • C. Toothill
    • 2
  1. 1.Division of AnaesthesiaClinical Research CentreHarrow, MiddlesexUK
  2. 2.Department of Chemical PathologyUniversity of LeedsLeedsUK

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