Determination of Cerebral Cortical Capillary Blood Volume from Mean Transit Time Analysis
A full understanding of the delivery of oxygen to a tissue cannot be attained by study of the blood flow to that tissue alone. An important component of the delivery system is the particular spatial arrangement of the capillaries supplying the tissue. This is especially critical in capillary networks that function through dynamic control of local tissue perfusion by regulating the number of open and closed capillaries. This form of vascular regulation has been generally known as ‘capillary recruitment’ and this concept implies that there are dynamic changes in tissue blood volume in response to changes in tissue metabolic demand. Capillary recruitment has long been suspected of being an integral part of cerebrovascular function, but until recently, experimental evidence for significant participation has been lacking (Weis et al., 1982; Pardridge and Fierer, 1985).
KeywordsCerebral Blood Flow Cerebral Blood Volume Mean Transit Time Strip Chart Recorder Capillary Recruitment
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