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The Effect of Intracellular Oxygen Concentration on Ventricular Fibrillation in Perfused Rat Heart

  • M. Makiguchi
  • H. Kawaguchi
  • H. Yasuda
  • M. Tamura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 215)

Abstract

From the clinical viewpoint, the patients with hypoxaemia have a high incidence of ventricular arrhythmias. However, there have been diverse results in animal models (Turnbull et al., 1965; Szekeres and Papp, 1967; Rogers et al., 1973; Murnaghan, 1975) possibly due to the effects of extracardiac factors such as neurohumoral reflex. To exclude such factors, we used an isolated perfused heart preparation to examine the direct effects of hypoxia on the arrhythmia. In this study, measuring the ventricular fibrillation threshold (VFT) in the isolated perfused rat heart, we examined the oxygen dependence of the susceptibility to ventricular fibrillation quantitatively under various conditions.

Keywords

Ventricular Fibrillation Ventricular Pressure Pyridine Nucleotide Epinephrine Infusion Oxygen Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Makiguchi
    • 1
  • H. Kawaguchi
    • 1
  • H. Yasuda
    • 1
  • M. Tamura
    • 2
  1. 1.Department of Cardiovascular MedicineSchool of MedicineJapan
  2. 2.Biophysics Division, Research Institute of Applied ElectricityHokkaido UniversitySapporo 060Japan

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