Metabolic, Ionic and Electrical Activities during and after Incomplete or Complete Cerebral Ischaemia in the Mongolian Gerbil
During the last 10 years the Mongolian gerbil (Meriones unguiculatus) has been adopted as an animal model for cerebral ischaemia because of the incompleteness of its Circle of Willis (Levy and Brierley, 1974; Levy, Brierley and Plum, 1975; Kobayashi, Lust and Passonneau, 1977; Levy and Duffy, 1977). The posterior connection between the vertebro-basilar and the carotid arteries is missing in all animals hence complete cerebral ischaemia develops after bilateral carotid artery occlusion. The degree of connection between the two anterior cerebral arteries varies in different individuals, so with unilateral carotid artery occlusion, the level of ischaemia developing in the ipsilateral hemisphere can vary between 0 and 100%. Using fibre optic surface fluorometry we monitored the intramitochondrial NADH redox state under partial or complete ischaemia in the gerbil brain (Mayevsky, Lebourdais and Chance, 1980; Mayevsky, Zarchin and Friedli, 1982; Mayevsky and Chance, 1983). The purpose of the present study was: 1) to correlate the degree of ischaemia developed under unilateral and bilateral carotid artery occlusion with the impairment of ionic homeostasis developed under these conditions; 2) to test the recovery rate of the extracellular K+ level (K e + ) under the same conditions.
KeywordsAnterior Cerebral Artery Light Guide Mongolian Gerbil Carotid Artery Occlusion Ischaemic Episode
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