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Cerebral Microcirculatory Changes during Exposure to Hypoxia

  • P. Weinbrecht
  • I. Longmuir
  • J. Knopp
  • M. Mills
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 215)

Summary

Changes in the red blood cell content of the cat cerebral cortical vessels were monitored using reflecting light during a decrease in PIO2. The following observations were made:
  1. 1)

    the capillary bed red blood cell content increased during hypoxia prior to the arteriole response at an arterial oxygen tension of 52.0 mmHg;

     
  2. 2)

    at arterial oxygen tensions below 52 mmHg the red blood cell content increased in all vessels simultaneously;

     
  3. 3)

    as the PIO2 decreased, the increase in red blood cell content occurred earlier in all vessels.

     
Capillaries, therefore, can respond to hypoxia independently of the arteriole in cat cerebal cortical tissue.

Keywords

Oxygen Transport Arterial Oxygen Tension Reflectance Signal Cerebral Microvasculature Deep Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Benson, D.M., Knopp, J.A. and Longmuir, I.S. (1981). Effect of optical configuration and tissue absorbance on the depth of light penetration in light microscopy. Fed. Proc. 40, 587.Google Scholar
  2. Longmuir, I.S., Knopp, J.A. and Pittman, J.L. (1984). Changes in cerebral oxygen tension and red cell content on sensory stimulation. In: Oxygen Transport to Tissue-VI. Eds Bruley, D., Bicher, H.I. and Reneau, D., Plenum Press, New York and London, ( Adv. Exp. Med. Biol. 180, 185–190 ).Google Scholar
  3. Longmuir, I.S.,Knopp, J.A. and Weinbrecht, P.T. (1985). Capillary red cell residence as a measure of tissue oxygen delivery. In: Oxygen Transport to Tissue-VII. Eds Kreuzer,F., Cain, S.M., Turek, Z. and Goldstick, T.K., Plenum Press, New York and London, ( Adv. Exp. Med. Biol. 191, 917–921 ).Google Scholar
  4. Weinbrecht, P.T., Johnson, L., Longmuir, I.S. and Knopp, J.A. (1986). Influence of Pa02 on cerebral macro-and microcirculation as observed by light reflection: time course of changes. In: Oxygen Transport to Tissue-VIII. Ed. Longmuir, I.S., Plenum Press, New York and London, ( Adv. Exp. Med. Biol. 200, 131–136 ).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. Weinbrecht
    • 1
  • I. Longmuir
    • 1
  • J. Knopp
    • 1
  • M. Mills
    • 1
  1. 1.Department of BiochemistryNorth Carolina State UniversityRaleighUSA

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