Changes in the Endoplasmic Reticulum Following Exposure to Hypoxia

  • W. F. Betts
  • I. S. Longmuir
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 215)


The effects of severe hypoxia on mammals are well documented. If hypoxia occurs abruptly death may follow. However, if the arterial oxygen tension falls gradually the organism may survive. It has become clear that many changes in the tissue occur during such hypoxia. Tissue changes which take place under these conditions may perform an acclimatizing role to assist in the organism’s survival. The purpose of this paper is to report a study of changes in hypoxic tissue at the subcellular level that may constitute the mechanism of acclimation.


Oxygen Transport Hypoxic Tissue Propylene Oxide Sodium Dithionite Arterial Oxygen Tension 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • W. F. Betts
    • 1
  • I. S. Longmuir
    • 1
  1. 1.Department of BiochemistryNorth Carolina State UniversityRaleighUSA

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