Arterial Obstruction Induced by PAF-Acether (1-0-Alkyl-SN-Glycero-3-Phosphocholine)
Platelet activating factor (PAF-acether) is a very potent mediator which is involved in many inflammatory and allergic reactions (Demopoulos, Pinckard and Hanahan, 1979; Vargaftig et al., 1981). Since its discovery in 1972 by Benveniste, Henson and Cochrane it has been demonstrated that this agent can induce leukopenia (O’Flaherty et al., 1981) and plasma leakage at the venular site of the vascular compartment (Bjork et al., 1983) followed eventually by arterial hypotension and death. In a previous paper (Bourgain et al., 1985), we demonstrated the effect of PAF-acether on the arterial wall in the guinea-pig following topical superfusion of the mediator in well standardized conditions. It became evident from these investigations that within two to three minutes following a three minute application of the mediator (10−7 M), a platelet thrombus developed at the site of superfusion. Over time, this platelet thrombus recruited leukocytes; these invaded the thrombotic mass and simultaneously underwent diapedesis. It happened that fragments of the thrombotic mass detached from the main structure and embolized; nevertheless the thrombus increased in size and occlusion of the vascular lumen occasionally occurred, leading to peripheral ischaemia and tissue hypoxia.
KeywordsArterial Segment Vascular Lumen Plasma Leakage Bleb Formation Arterial Obstruction
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