Diffusion Pathways in Oxygen Supply of Cardiac Muscle

  • L. Hoofd
  • Z. Turek
  • K. Rakusan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 215)


In modelling oxygen transport in tissue, it is generally accepted that the oxygen in this medium has to be transported by diffusion. It is not quite clear, however, along which routes this O2 diffusion occurs. Such routes can be spatial and functional. A spatially different diffusion route is an alternative pathway in the tissue, whereas facilitated diffusion via binding to myoglobin is an example of a functionally different additional transport route. Examples of both types will be considered here.


Oxygen Transport Diffusion Area Diffusion Route Tissue Cylinder Asymmetric Region 
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  1. de Koning, J., Hoofd, L.J.C. and Kreuzer, F. (1981). Oxygen transport and the function of myoglobin. Theoretical model and experiments in chick gizzard smooth muscle. Pflugers Arch. 389, 211–217.CrossRefGoogle Scholar
  2. Federspiel, W.J. (1986). A model study of intracellular oxygen gradients in a myoglobin-containing skeletal muscle fiber. Biophys. J. 49, 857–868.CrossRefGoogle Scholar
  3. Hoofd, L.J.C. (1986). Facilitated diffusion of oxygen in tissue and model systems. Thesis, Catholic University, Nijmegen.Google Scholar
  4. Hoofd, L., Turek, Z., Kubat, K., Ringnalda, B.E.M. and Kazda, S. (1985). Variability of intercapillary distance estimated on histological sections of rat heart. In: Oxygen Transport to Tissue-VII. Eds Kreuzer, F., Cain, S.M., Turek, Z. and Goldstick, T.K., Plenum Press, New York and London, ( Adv. Exp. Med. Biol. 191, 239–247 ).Google Scholar
  5. Kreuzer, F. (1982). Oxygen supply to tissues: the Krogh model and its assumptions. Experientia, 38, 1415–1426.CrossRefGoogle Scholar
  6. Krogh, A. (1919). The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J. Physiol. 52, 409–415.Google Scholar
  7. Rakusan, K., Hoofd, L. and Turek, Z. (1984). The effect of cell size and capillary spacing on myocardial oxygen supply. In: Oxygen Transport to Tissue-VI. Eds Bruley, D., Bicher, H.I. and Reneau, D., Plenum Press, New York and London, ( Adv. Exp. Med. Biol. 180, 463–477 ).Google Scholar
  8. Turek, Z., Hoofd, L. and Rakusan, K. (1986). Myocardial capillaries and tissue oxygenation. Can. J. Cardiol. 2, 98–103.Google Scholar
  9. Turek, Z., Hoofd, L. and Rakusan, K. (1987). A comparison of the methods for assessment of the heterogeneity of myocardial capillary spacing. This volume.Google Scholar
  10. Turek, Z. and Rakusan, K. (1981). Lognormal distribution of inter-capillary distance in normal and hypertrophic rat heart as estimated by the method of concentric circles: its effect on tissue oxygenation. Pflugers Arch. 391, 17–21.CrossRefGoogle Scholar
  11. Turek, Z. Ringnalda, B.E.M., Grandtner, M. and Kreuzer, F. (1973). Myoglobin distribution in the heart of growing rats exposed to a simulated altitude of 3500 m in their youth or born in the low pressure chamber. Pflugers Arch. 340, 1–10.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • L. Hoofd
    • 1
  • Z. Turek
    • 1
  • K. Rakusan
    • 2
  1. 1.Department of Physiology, Medical FacultyCatholic UniversityNijmegenThe Netherlands
  2. 2.Department of Physiology, School of MedicineUniversity of OttawaOttawaCanada

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