Emulsified Perfluorochemicals as Physiological Oxygen-Transport Fluids: Assessment of a Novel Formulation

  • S. K. Sharma
  • A. D. Bollands
  • S. S. Davis
  • K. C. Lowe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 215)


Emulsions of perfluorochemicals (PFC) in isotonic electrolyte solutions are known to have properties which make them attractive as physiological oxygen-transport fluids. Such properties include: the ability to dissolve substantial volumes of oxygen and other respiratory gases; and their small particle sizes (< 0.25 µm) which enable them to pass through capillary beds. In addition, due to the strength of the carbon-fluorine bond (ca. 116 kcal/mol), the PFC themselves are generally regarded as being both chemically and biologically inert (Riess and Le Blanc, 1982). Some of the physiological effects of emulsified PFC have been studied in several species and also in experiments using mammalian cells in culture (Lowe and Bollands, 1985; Lowe, 1986).


Mesenteric Lymph Node Tissue Weight Oxygen Carrier Ostwald Ripening Ethyl Palmitate 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. K. Sharma
    • 1
  • A. D. Bollands
    • 2
  • S. S. Davis
    • 1
  • K. C. Lowe
    • 2
  1. 1.Departments of PharmacyUniversity of NottinghamUniversity Park, NottinghamUK
  2. 2.Departments of ZoologyUniversity of NottinghamUniversity Park, NottinghamUK

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