Role of Xanthine Oxidase and Granulocytes in Ischemia/Reperfusion Injury

  • Matthew B. Grisham
  • Barbara J. Zimmerman
  • D. Neil Granger
Part of the NATO ASI Series book series (NSSA, volume 189)


The concept that xanthine oxidase—derived oxidants mediate the microvascular injury associated with reperfusion of the ischemic intestine was first proposed in 1981 (1). Since its inception most of the assumptions inherent in this concept have been tested and it has been extended to a number of other organ systems (2). The information derived from several studies performed in our laboratory and by others have led us to revise the biochemical scheme originally proposed to explain oxygen-dependent reperfusion injury. The revised scheme (Figure 1) assumes that xanthine oxidase—derived oxidants produced following reoxygenation of ischemic intestine play an important role in recruiting and activating granulocytes, which ultimately mediate reperfusion—induced microvascular injury. The foregoing discussion will summarize the supporting evidence presented in Figure 1.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Matthew B. Grisham
    • 1
  • Barbara J. Zimmerman
    • 1
  • D. Neil Granger
    • 1
  1. 1.Department of Physiology and Biophysics LSU Medical CenterShreveportUSA

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