Quinone Redox Cycling and the Protective Effect of DT Diaphorase

  • Helmut Sies
Part of the NATO ASI Series book series (NSSA, volume 189)


The one-electron oxidation-reduction cycling of quinones, semiquinones and hydroquinones contributes to the generation of reactive oxygen species and, consequently, toxicity, carcinogenicity and cell damage, e.g. to enzymes, DNA and membranes. In this process of redox cycling, interest has focused on the biochemistry, molecular biology, toxicology and physiology of the enzyme, NADPH:quinone oxidoreductase, also known as DT diaphorase, catalyzing the two-electron reduction of quinones.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Helmut Sies
    • 1
  1. 1.Institut für Physiologische Chemie IUniversität Düsseldorf Moorenstrasse 5DüsseldorfGermany

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