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Lipid Peroxidation and Cellular Functions: in Vitro Models and Relation to in Vivo Observations

  • Chapter
Free Radicals, Lipoproteins, and Membrane Lipids

Part of the book series: NATO ASI Series ((NSSA,volume 189))

Summary

The consequences of lipid peroxidation on various cell metabolisms are reviewed with special emphasis on low density lipoprotein catabolism and its relation to atherosclerosis. We also present results concerning an original model developed in our laboratories for the study of the effects of singlet oxygen on lipid peroxidation. In this experimental model, lipoproteins are used as a lipidic environment for porphyrins generating singlet oxygen during their photoactivation. We demonstrate that singlet oxygen attack results in the appearance of fatty acid and cholesterol peroxidation products and in alterations of apolipoproteins, but that apolipoprotein alterations markedly differ between low density and high density lipoproteins. Besides its theoretical interest for the study of lipid oxidation in lipid-protein complexes, this model brings new data concerning the consequences of the photoactivation of anticancer porphyrins which are carried by plasma lipoproteins, mainly LDL and HDL.

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Authors and Affiliations

  1. Laboratoire de Biochimie, Faculté de Médicine Saint-Antoine, 27 rue Chaligny, Paris, France

    J. C. Mazière, S. Salmon, C. Candide & C. Mazière

  2. Laboratoire de Physico-Chimie de l’Adaptation Biologique, Muséum d’Histoire Naturelle de Paris, INSERM U 312, 45 rue Cuvier, 75005, Paris, France

    R. Santus & J. P. Reyftmann

  3. Laboratoire de Recherche Dermatologique, INSERM U 312, Hôpital Henri Mondor, 94010, Créteil, France

    P. Morlière & L. Dubertret

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  1. J. C. Mazière
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  2. S. Salmon
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  3. C. Candide
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  4. C. Mazière
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  5. R. Santus
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  6. J. P. Reyftmann
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  7. P. Morlière
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Editors and Affiliations

  1. INSERM Unit 58, Montpellier, France

    A. Crastes de Paulet

  2. INSERM Unit 101, Toulouse, France

    L. Douste-Blazy

  3. University of Milan, Milan, Italy

    R. Paoletti

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© 1990 Plenum Press, New York

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Mazière, J.C. et al. (1990). Lipid Peroxidation and Cellular Functions: in Vitro Models and Relation to in Vivo Observations. In: de Paulet, A.C., Douste-Blazy, L., Paoletti, R. (eds) Free Radicals, Lipoproteins, and Membrane Lipids. NATO ASI Series, vol 189. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7427-5_31

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  • DOI: https://doi.org/10.1007/978-1-4684-7427-5_31

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7429-9

  • Online ISBN: 978-1-4684-7427-5

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