Triggering and Regulation of the Free Radical Production by Phagocytes

  • P. Bellavite
  • M. C. Serra
  • F. Bazzoni
  • S. Miron
  • S. Dusi
Part of the NATO ASI Series book series (NSSA, volume 189)


Phagocytic cells (neutrophils, eosinophils, monocytes and macrophages) are capable of converting oxygen into potentially toxic species such as superoxide anion, hydrogen peroxide and hydroxyl radical. This peculiar metabolic pathway, which is called respiratory burst, is turned on when a membrane — bound enzyme, the NADPH oxidase, is activated. Other reactions, such as those of the glutathione cycle and of the hexose monophosphate pathway, are secondary to the triggering of NADPH oxidase, having the function of continuouslsupply of reduced NADPH and of intracellular detoxification.1–3


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • P. Bellavite
    • 1
  • M. C. Serra
    • 1
  • F. Bazzoni
    • 1
  • S. Miron
    • 1
  • S. Dusi
    • 1
  1. 1.Istituto di Patologia GeneraleUniversità di VeronaVeronaItaly

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