Mechanisms of Hydroperoxide-Induced Broncho- and Vasoconstriction in the Perfused Rat Lung
Active forms of oxygen are now recognized as important factors in the etiology of lung diseases such as chronic bronchitis and emphysema. Reactive species such as the superoxide anion radical (O2 ָ), hydrogen peroxide (H2O2) and the hydroxyl (.OH) radical may be formed as a consequence of inflammation which is generally a result of excessive cigarette smoking and environmental factors. Oxidative stress may also be caused directly by components present in cigarette smoke such as polymeric phenoxy radicals, hydroperoxides and other oxidative reactive agents. Experimentally, active oxygen species generated enzymatically in the air-passages have been shown to cause pulmonary toxicity.1 Pulmonary toxicity has also been observed to be caused by stimulated granulocytes.2 This damage has been postulated to be due to direct oxidative damage by reactive oxidants produced by the granulocytes.
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