A New Model System for Studying the Cytotoxicity of Peroxidized Lipoproteins in Cultured Cells

  • R. Salvayre
  • A. Nègre
  • M. Lopez
  • N. Dousset
  • T. Levade
  • A. Maret
  • M. T. Pieraggi
  • L. Douste-Blazy
Part of the NATO ASI Series book series (NSSA, volume 189)


Free radicals can be generated by physical agents, e.g. ionizing radiations1 , 2 as well as by a wide variety of biochemical reactions occuring in living organisms 3 , 4 , 5. Transition metals seem to play a major role in the interconversion of oxygen free radical species, for example in the Haber-Weiss reaction6, 7. Lipid peroxidation induced by free radical attack is amplified by autocatalytic cycles generating in turn lipid peroxide free radicals; this “propagation” step leads to the “termination” step which is characterized by the formation of non-radical compounds such as short chain aldehydes, ketones, alkanes, carboxylic acids, lipid dimers6.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • R. Salvayre
    • 1
  • A. Nègre
    • 1
  • M. Lopez
    • 1
  • N. Dousset
    • 1
  • T. Levade
    • 1
  • A. Maret
    • 1
  • M. T. Pieraggi
    • 2
  • L. Douste-Blazy
    • 1
  1. 1.Laboratoire de Biochimie, INSERM 101Faculté de MédecineToulouse CedexFrance
  2. 2.Anatomie PathologiqueCHU RangueilToulouseFrance

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