The Role of Oxidative Metabolism and Antioxidants in Low-Density Lipoprotein Structure and Metabolism
The mechanisms by which free radicals mediate alterations in the structure and function of proteins, both in aqueous and lipid-containing (e.g. membranes and lipoproteins) systems, are of relevance in many normal and pathological conditions, since proteins are frequently the components of biological systems which are responsible for functional activity and specificity. We describe here studies of these processes in human low-density lipoprotein, and their likely relevance to atherogenesis.
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- 8.. U.P. Steinbrecher, Role of superoxide in endothelial-cell modification of low-density lipoproteins., Biochim. Biophys. Acta 959: 20 (1988).Google Scholar
- 10.. V.W.M. van Hinsbergh, M. Scheffer, L. Havekes and H.J. van Kempen, Role of endothelial cells and their products in the modification of low density lipoproteins., Biochim. Biophys. Acta, 878: 49 (1986).Google Scholar
- 12.. D.W.S. Bilheimer, S. Eisenberg and R.I. Levy, The metabolism of very low-density lipoproteins. Biochim. Biophys. Acta 60: 212 (1972).Google Scholar
- 13.. R.T. Dean, C.R. Roberts and W. Jessup, Fragmentation of intracellular and extracellular polypeptides by free radicals, in: “Intracellular protein catabolism,” E.A. Khairallah, J.S. Bond and J.W.C. Bird, eds., A.R. Liss, New York (1985).Google Scholar
- 15.S.M. Thomas, W. Jessup, J.M. Gebicki and R.T. Dean, A continuous-flow automated assay for iodometric estimation of hydroperoxides., Anal. Biochem., 176:in press (1988).Google Scholar
- 25.. R.T. Dean, S.M. Thomas, G. Vince and S.P. Wolff, Oxidation induced proteolysis and its possible restriction by some secondary protein modifications., Biomed. Biochim. Acta 45: 1563 (1986).Google Scholar
- 27.. B. Halliwell and J.M.C. Gutteridge, “Free radicals in biology and medicine,” Oxford University Press, Oxford (1985).Google Scholar
- 28.S.M. Rankin, J.R.S. Moult and D.S. Leake, Effects of flavonoids on the oxidative modification of low density lipoproteins by macrophages, Brit. J. Immunol., in press (1988).Google Scholar
- 29.W. Bors, H. Heller, C. Michel and M. Saran, Flavonoids as antioxidants. Determination of their radical scavenging efficiencies. Methods in Enzymology, in press. (1988)Google Scholar