Lipid Peroxidation by Phagocytes

  • Bernard M. Babior
Part of the NATO ASI Series book series (NSSA, volume 189)


Professional phagocytes (neutrophils, eosinophils, mononuclear phagocytes) are uniquely endowed with the capacity to manufacture large quantities of highly reactive oxidizing agents for use in the destruction of invading pathogens, both unicellular and multicellular. This capacity arises because of the presence in these cells of an enzyme known as the respiratory burst oxidase that catalyzes the one-electron reduction of oxygen to 02 at the expense of NADPH


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. B. Samuelsson, M. Goldyne, E. Granstrom, M. Hamberg, S. Hammarstrom, and C. Malmsten, Prostaglandins and thromboxanes. Ann. Rev. Biochem. 47:997, 1978.CrossRefGoogle Scholar
  2. 2.
    B. Samuelsson, S.-E. Dahlen, J.-A. Lindgren, C.A. Rouzer, and C.N. Serhan, Leukotrienes and Lipoxins: Structures, biosynthesis, and biological effects. Science 237: 1171, 1987.PubMedGoogle Scholar
  3. R.J. Mason, T.P. Stossel, and M. Vaughan, Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles. J. Clin. Invest. 51:2399, 1972.CrossRefGoogle Scholar
  4. S.M. Sepe, and R.A. Clark, Oxidant membrane injury by the neutrophil myeloperoxidase system. J. Immunol. 134:1888–1895, 1985.Google Scholar
  5. 5.
    S.M. Sepe, and R.A. Clark, Oxidant membrane injury by the neutrophil myeloperoxidase system. II. Injury by stimulated neutrophils and protection by lipid-soluble antioxidants. J. Immunol. 134: 1896, 1985.PubMedGoogle Scholar
  6. C.W. Lee, R.A. Lewis, A.I. Tauber, M. Mehrotra, E.J. Corey, and K.F. Austen, The myeloperoxidase-dependent metabolism of leukotrienes C4, D4, and E4 to 6-trans-leukotriene B4 diastereoisomers sulfoxides. J. Biol. Chem. 258:15004–10, 1983.Google Scholar
  7. 7.
    S. Claster, D.T. Chiu, A. Quintanilha, B. Lubin, Neutrophils mediate lipid peroxidation in human red cells. Blood 64: 107984, 1984.Google Scholar
  8. M.S. Cohen, B.E. Britigan, D.J. Hassett, and G.M. Rosen, Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy. J. Free Radic. Biol. Med. 5:81–88, 1988.CrossRefGoogle Scholar
  9. A. Samuni, C.D. Black, C.M. Krishna, H.L. Malech, E.F. Bernstein, and A. Russo, Hydroxyl radical production by stimulated neutrophils reappraised. J. Biol. Chem. 263:13797–13801, 1988.Google Scholar
  10. G. Carlin, and K.E. Arfors, Peroxidation of liposomes promoted by human polymorphonuclear leucocytes. J. Free Radic. Biol. Med. 1:437–442, 1985.CrossRefGoogle Scholar
  11. G. Minotti, and S.D. Aust, The requirement for the iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide. J. Biol, Chem. 262:1098–1104, 1987.Google Scholar
  12. G. Carlin, Peroxidation of linolenic acid promoted by human polymorphonuclear leucocytes. J. Free Radic. Biol. Med. 1:255261, 1985.CrossRefGoogle Scholar
  13. 13.
    P.A. Ward, K.J. Johnson, and G.O. Till, Animal models of oxidant lung injury. Respiration 50: 5–12, 1986.PubMedGoogle Scholar
  14. D. Royston, J.S. Fleming, J.B. Desai, S. Westaby, and K.M. Taylor, Increased production of peroxidation products associated with cardiac operations. Evidence for free radical generation. J. Throac. Cardiovasc. Surg. 91:759–766, 1986.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Bernard M. Babior
    • 1
  1. 1.Department of Molecular and Experimental MedicineResearch Institute of Scripps ClinicLa JollaUSA

Personalised recommendations