The Neutrophil pp 149-176 | Cite as

Degranulation and Intracellular Killing of Bacteria

  • Patrick Murphy


Metchnikoff knew that neutrophils possessed “ferments” capable of digesting gelatin and other proteins, and that phagocytosed grains of litmus sometimes turned red. He knew that organisms taken up by neutrophils were enclosed in vacuoles and not admitted to the cytoplasm proper, and that in the vacuoles they were slowly digested. He said:

We are at present ignorant of the precise manner in which this digestive and other destructive action is accomplished, and do not even know whether the substance which kills the microbes is a ferment or not.


NADPH Oxidase Chronic Granulomatous Disease Respiratory Quotient Cationic Protein NADH Oxidase 
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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Patrick Murphy
    • 1
  1. 1.The Johns Hopkins University School of MedicineBaltimoreUSA

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