Advertisement

Tissue Consumption of Granulocytes and Control Mechanisms for Granulopoiesis

  • Patrick Murphy

Abstract

The reader in search of hard scientific information would do well to skip this chapter altogether, because it is constructed from a few wattles of established fact and large quantities of speculative daub. It was shown in the last chapter that enormous numbers of neutrophils are produced in the marrow, enter the bloodstream, and rapidly leave the blood for the tissues. Intuitively, one would suppose that their function was to combat bacterial infections, and that the cells would emigrate chiefly from blood vessels in those areas of the body where large bacterial populations are normally carried. If this were so, there should be heavy emigration of labeled neutrophils into the mouth, the gastrointestinal tract, the upper airway, and perhaps the skin, and very little into normally sterile areas, such as the brain and skeletal muscle. How far does the available evidence support this picture?

Keywords

Neutrophil Count Blood Neutrophil Neutrophil Leukocytosis General Lymphocyte Activator Epidermal Chalone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Godwin, K. O., Fraser, F. J., and Ibbotson, R. N., Haematological observations on healthy (SPF) rats, Br. J. Exp. Pathol. 45:514 (1964).PubMedGoogle Scholar
  2. 2.
    Fleidner, T. M., Fache, I., and Adolphi, C., Über die Umsatzkinetik der Leukocyten bei keimbreien Mäusen, Schweiz. Med. Wochenschr. 96:1236 (1966).Google Scholar
  3. 3.
    Boggs, D. R., Cheverick, P. A., Marsh, J. C., et al., Granulocytopoiesis in germ-free mice, Proc. Soc. Exp. Biol. Med. 125:325 (1967).PubMedGoogle Scholar
  4. 4.
    Schulz, R. Z., Warren, M. F., and Drinker, C. K., The passage of virulent type III pneumococci from the respiratory tract of rabbits into the lymphatics and blood, J. Exp. Med. 68:251 (1938).PubMedCrossRefGoogle Scholar
  5. 5.
    Ambrus, C. M., and Ambrus, J. L., Regulation of the leukocyte level, Ann. N.Y. Acad. Sci. 77:445 (1959).PubMedCrossRefGoogle Scholar
  6. 6.
    Galbraith, P. R., Valberg, L. S., and Brown, M., Patterns of granulocyte kinetics in health, infection and in carcinomas, Blood 25:683 (1965).PubMedGoogle Scholar
  7. 7.
    Gordon, A. S., Neri, R. O., Siegel, C. D., et al., Evidence for a circulating leucocytosis-inducing factor (L.I.F.), Acta Haematol. 23:323 (1960).PubMedCrossRefGoogle Scholar
  8. 8.
    Craddock, C.G., Adams, W. S., Perry, S., et al., The technique of leukophoresis and the response of myeloid tissue in normal and irradiated dogs, J. Lab. Clin. Med. 45:881 (1955).PubMedGoogle Scholar
  9. 9.
    Boggs, D. R., Cartwright, G. E., and Wintrobe, M. M., Neutrophilia-inducing activity in plasma of dogs recovering from drug-induced myelotoxicity, Am. J. Physiol. 211:51 (1966).PubMedGoogle Scholar
  10. 10.
    Bullough, W. S., and Laurence, E. B., The control of epidermal mitotic activity in the mouse, Proc. R. Soc. London Ser. B. 151:517 (1960).CrossRefGoogle Scholar
  11. 11.
    Rytomaa, T., and Kiviniemi, K., Control of granulocyte production. I. Chalone and anti chalone; two specific humoral regulators. II. Mode of action of chalone and anti chalone, Cell Tissue Kinet. 1:329, 341 (1968).Google Scholar
  12. 12.
    Paukovits, W. R., Granulopoiesis-inhibiting factor: Demonstration and preliminary chemical and biological characterization of a specific polypeptide (chalone), Nat. Cancer Inst. Monogr. 38:143 (1973).Google Scholar
  13. 13.
    Rytomaa, T., and Kiviniemi, K., Chloroma regression induced by the granulocytic chalone, Nature London 222:995 (1969).PubMedCrossRefGoogle Scholar
  14. 14.
    Metcalf, D., and Moore, M. A. S., Regulation of growth and differentiation in hemopoietic colonies growing in agar, in: Haemopoietic Stem Cells, Ciba Foundation Symposium 13 (new series), p. 157.Google Scholar
  15. 15.
    Morley, A., and Stohlman, F., Cyclophosphamide induced cyclical neutropenia, N. Engl. J. Med. 282:643 (1970).PubMedCrossRefGoogle Scholar
  16. 16.
    Morley, A., Howard, D., Bennett, B., et al., Studies on the regulation of granulopoiesis. II. Relationship to other differentiation pathways, Br. J. Haematol. 19:523 (1970).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Patrick Murphy
    • 1
  1. 1.The Johns Hopkins University School of MedicineBaltimoreUSA

Personalised recommendations