Abstract
The reader in search of hard scientific information would do well to skip this chapter altogether, because it is constructed from a few wattles of established fact and large quantities of speculative daub. It was shown in the last chapter that enormous numbers of neutrophils are produced in the marrow, enter the bloodstream, and rapidly leave the blood for the tissues. Intuitively, one would suppose that their function was to combat bacterial infections, and that the cells would emigrate chiefly from blood vessels in those areas of the body where large bacterial populations are normally carried. If this were so, there should be heavy emigration of labeled neutrophils into the mouth, the gastrointestinal tract, the upper airway, and perhaps the skin, and very little into normally sterile areas, such as the brain and skeletal muscle. How far does the available evidence support this picture?
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Godwin, K. O., Fraser, F. J., and Ibbotson, R. N., Haematological observations on healthy (SPF) rats, Br. J. Exp. Pathol. 45:514 (1964).
Fleidner, T. M., Fache, I., and Adolphi, C., Über die Umsatzkinetik der Leukocyten bei keimbreien Mäusen, Schweiz. Med. Wochenschr. 96:1236 (1966).
Boggs, D. R., Cheverick, P. A., Marsh, J. C., et al., Granulocytopoiesis in germ-free mice, Proc. Soc. Exp. Biol. Med. 125:325 (1967).
Schulz, R. Z., Warren, M. F., and Drinker, C. K., The passage of virulent type III pneumococci from the respiratory tract of rabbits into the lymphatics and blood, J. Exp. Med. 68:251 (1938).
Ambrus, C. M., and Ambrus, J. L., Regulation of the leukocyte level, Ann. N.Y. Acad. Sci. 77:445 (1959).
Galbraith, P. R., Valberg, L. S., and Brown, M., Patterns of granulocyte kinetics in health, infection and in carcinomas, Blood 25:683 (1965).
Gordon, A. S., Neri, R. O., Siegel, C. D., et al., Evidence for a circulating leucocytosis-inducing factor (L.I.F.), Acta Haematol. 23:323 (1960).
Craddock, C.G., Adams, W. S., Perry, S., et al., The technique of leukophoresis and the response of myeloid tissue in normal and irradiated dogs, J. Lab. Clin. Med. 45:881 (1955).
Boggs, D. R., Cartwright, G. E., and Wintrobe, M. M., Neutrophilia-inducing activity in plasma of dogs recovering from drug-induced myelotoxicity, Am. J. Physiol. 211:51 (1966).
Bullough, W. S., and Laurence, E. B., The control of epidermal mitotic activity in the mouse, Proc. R. Soc. London Ser. B. 151:517 (1960).
Rytomaa, T., and Kiviniemi, K., Control of granulocyte production. I. Chalone and anti chalone; two specific humoral regulators. II. Mode of action of chalone and anti chalone, Cell Tissue Kinet. 1:329, 341 (1968).
Paukovits, W. R., Granulopoiesis-inhibiting factor: Demonstration and preliminary chemical and biological characterization of a specific polypeptide (chalone), Nat. Cancer Inst. Monogr. 38:143 (1973).
Rytomaa, T., and Kiviniemi, K., Chloroma regression induced by the granulocytic chalone, Nature London 222:995 (1969).
Metcalf, D., and Moore, M. A. S., Regulation of growth and differentiation in hemopoietic colonies growing in agar, in: Haemopoietic Stem Cells, Ciba Foundation Symposium 13 (new series), p. 157.
Morley, A., and Stohlman, F., Cyclophosphamide induced cyclical neutropenia, N. Engl. J. Med. 282:643 (1970).
Morley, A., Howard, D., Bennett, B., et al., Studies on the regulation of granulopoiesis. II. Relationship to other differentiation pathways, Br. J. Haematol. 19:523 (1970).
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© 1976 Plenum Publishing Corporation
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Murphy, P. (1976). Tissue Consumption of Granulocytes and Control Mechanisms for Granulopoiesis. In: The Neutrophil. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7418-3_5
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DOI: https://doi.org/10.1007/978-1-4684-7418-3_5
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